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Article: Alterations in GABA(A) receptor mediated inhibition in adjacent dorsal midline thalamic nuclei in a rat model of chronic limbic epilepsy.

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Rajasekaran K; Kapur J; Bertram EH
J. Neurophysiol., 2007


TABLE 2.

mIPSC alterations in the mediodorsal and paraventricular thalamus of animals with chronic limbic epilepsy

(n = Cells/Animals) Mediolateral Thalamus Paraventricular Thalamus
Control (32/16) Epilepsy (20/12) Control (31/12) Epilepsy (17/12)
Frequency, Hz 0.25 ± 0.02 0.25 ± 0.03 0.20 ± 0.02 0.59 ± 0.07***
Median amplitude, pA 84.89 ± 3.73 77.51 ± 2.99 85.68 ± 1.24 105.00 ± 1.64***
10–90% Rise time, ms 2.23 ± 0.09 2.18 ± 0.10 2.39 ± 0.13 2.34 ± 0.18
τ1 decay, ms 14.32 ± 1.09 12.51 ± 0.74 14.24 ± 0.78 11.66 ± 0.60*
τ1 decay, ms 42.66 ± 2.78 37.76 ± 3.96 37.85 ± 1.77 36.28 ± 3.86
τW decay, ms 27.57 ± 1.06 24.11 ± 1.57 25.39 ± 1.08 21.31 ± 0.93*
Net charge transfer, nA·min 4.53 ± 0.07 4.38 ± 0.12 4.49 ± 0.06 5.01 ± 0.17***
  • Values are means±SE. See methods for calculations.

  • * P < 0.05,

  • *** P < 0.0001 compared to control animals.


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