Article: Chronic changes in synaptic responses of entorhinal and hippocampal neurons after amino-oxyacetic acid (AOAA)-induced entorhinal cortical neuron loss.

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Scharfman HE; Goodman JH; Du F; Schwarcz R
J. Neurophysiol., 1998

Table 1.

Comparison of afferent responses recorded in hippocampus in AOAA-treated rats and controls in vitro

	Control	AOAA

Dentate gyrus
Population EPSP amplitude, mV	5.9 ± 0.30	5.6 ± 0.21
Population spike amplitude, mV	3.2 ± 0.66	2.8 ± 0.34
Paired-pulse inhibition 20 ms ISI, %	18.3 ± 6.9	11.8 ± 4.1
n	20	11
Area CA1
Population spike amplitude, mV, Schaffer collateral stimulation	12.1 ± 0.41	14.2 ± 0.43
Population spike amplitude, mV, stratum lacunosum-moleculare stimulation	11.4 ± 0.51	10.8 ± 0.32
Paired pulse inhibition 20 ms ISI, %	65.2 ± 8.1	60.2 ± 5.2
n	13	8

Values are means ± SE. Stimulus intensity was half the intensity that produced a maximal response. Sample sizes refer to the number of slices tested from the left hemisphere (hemisphere ipsilateral to the AOAA injection). Recording and stimulation sites are shown in Fig. 2. Amplitude calculations are described in methods. ISI, interstimulus interval. Paired-pulse inhibition is based on the ratio of the second response amplitude to the first and is expressed as a percent (see Methods). None of the differences between control and AOAA rats were statistically significant (P > 0.05; Student's t-test).

Inferred neuron-electrophysiology data values

Neuron Type	Ephys Prop	Extracted Value	Standardized Value	Content Source
Medial entorhinal cortex layer II stellate cell	spike amplitude (mV)	12.1 ± 0.41	--	Data Table
Medial entorhinal cortex layer II stellate cell	spike amplitude (mV)	11.4 ± 0.51	--	Data Table
Medial entorhinal cortex layer II stellate cell	spike amplitude (mV)	3.2 ± 0.66	--	Data Table