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Article: Neuromodulation by a cytokine: interferon-beta differentially augments neocortical neuronal activity and excitability.

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Hadjilambreva G; Mix E; Rolfs A; Müller J; Strauss U
J. Neurophysiol., 2005



TABLE 1.General sub- and suprathreshold membrane properties of somatosensory pyramidal neurons from the neocortex of Wistar rats


Layer 2/3 Layer 5

Membrane potential, mV –75.1 ± 0.9 (45) –72.6 ± 0.8 (47)
Input resistance, MΩ 34.8 ± 2.5 (45) 33.1 ± 2.5 (47)
Membrane time constant, ms 12.4 ± 0.8 (45) 14.1 ± 1.0 (47)
Action potential amplitude, mV 87.9 ± 1.2 (39) 83.2 ± 3.2 (24)
Action potential width at half height, ms 1.16 ± 0.03 (39) 1.06 ± 0.05 (24)
Action potential rise time (10–90%), ms 0.40 ± 0.01 (39) 0.36 ± 0.01 (24)
Action potential rate of rise, V/s 162.0 ± 7.5 (39) 182.3 ± 13.2 (24)
Rheobase (action potential current threshold), pA 206.8 ± 38.4 (21) 254.0 ± 48.7 (23)
F-I slope, Hz/nA 59.5 ± 6.6 (21) 64.6 ± 9.9 (23)

Data presented as mean ± SE, number of cells in parentheses. Note that the neurons under the pre-treatment with ZD7288 have been excluded from the analysis of the membrane properties. Analysis of single action potential and firing properties were restricted to those neurons which underwent related interferon-{beta} superfusion experiments.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Layer 2/3 somatosensory cortex pyramidal neurons input resistance (MΩ) 34.8 ± 2.5 (45) 34.8 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory pyramidal neurons input resistance (MΩ) 33.1 ± 2.5 (47) 33.1 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 somatosensory cortex pyramidal neurons membrane time constant (ms) 12.4 ± 0.8 (45) 12.4 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory pyramidal neurons membrane time constant (ms) 14.1 ± 1.0 (47) 14.1 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 somatosensory cortex pyramidal neurons spike amplitude (mV) 87.9 ± 1.2 (39) 87.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory pyramidal neurons spike amplitude (mV) 83.2 ± 3.2 (24) 83.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 somatosensory cortex pyramidal neurons spike half-width (ms) 1.16 ± 0.03 (39) 1.16 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory pyramidal neurons spike half-width (ms) 1.06 ± 0.05 (24) 1.06 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 somatosensory cortex pyramidal neurons spike rise time 0.4 ± 0.01 (39) 0.4 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory pyramidal neurons spike rise time 0.36 ± 0.01 (24) 0.36 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 somatosensory cortex pyramidal neurons spike max rise slope (V/s) 162.0 ± 7.5 (39) 162.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory pyramidal neurons spike max rise slope (V/s) 182.3 ± 13.2 (24) 182.3 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 somatosensory cortex pyramidal neurons rheobase 206.8 ± 38.4 (21) 206.8 (pA) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory pyramidal neurons rheobase 254.0 ± 48.7 (23) 254.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 somatosensory cortex pyramidal neurons FI slope (Hz/nA) 59.5 ± 6.6 (21) 59.5 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory pyramidal neurons FI slope (Hz/nA) 64.6 ± 9.9 (23) 64.6 (Hz/nA) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 somatosensory cortex pyramidal neurons resting membrane potential (mV) -75.1 ± 0.9 (45) -75.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 somatosensory pyramidal neurons resting membrane potential (mV) -72.6 ± 0.8 (47) -72.6 (mV) Data Table