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Article: Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons.

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Tao J; Liu P; Xiao Z; Zhao H; Gerber BR; Cao YQ
J. Neurophysiol., 2012


Table 2.

Voltage-dependence of activation of VGCCs in TG neurons

P/Q-Type Currents T-Type Currents in small IB4− TG Neurons
V50,tail, mV k, mV/e-fold change n V50,tail, mV k, mV/e-fold change n
EGFP −47.36 ± 2.33* 12.62 ± 2.31 16
hWT −12.09 ± 3.53 6.34 ± 0.86 5 −31.70 ± 1.78 12.37 ± 1.14 10
T666M −12.53 ± 2.96 7.46 ± 2.46 5 −44.53 ± 2.30* 11.61 ± 2.36 12

  • Values are means ± SE; n, number of neurons. VGCC, voltage-gated Ca2+ channels; V50,tail, half-voltage of voltage-dependent activation calculated from tail current; k, slope factor; EGFP, enhanced green fluorescent protein.

  • ↵* P < 0.01, compared with the human wild-type (hWT) group, one-way ANOVA with post hoc Bonferroni test.


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