TABLE 1.Summary of statistics on RS and FS cells
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Parameter | Regular-Spiking | Fast-Spiking | P |
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Number of cells | 20 | 23 | |
Maximum firing rate, Hz | 32.3 ± 7.0 | 61.0 ± 9.1 | <0.001 |
Resting potential, mV | –71.8 ± 3.5 | –71.2 ± 4.0 | — |
Input resistance, MΩ | 424.0 ± 189.7 | 357.4 ± 147.5 | — |
Time constant, ms | 41.2 ± 12.5 | 29.7 ± 5.9 | <0.005 |
Spike amplitude, mV | 78.1 ± 9.0 | 72.8 ± 6.5 | <0.05 |
AHP amplitude, mV | 7.3 ± 2.4 | 17.1 ± 4.1 | <0.001 |
1st spike width (W1), ms | 1.71 ± 0.36 | 1.18 ± 0.17 | <0.001 |
2nd spike width (W2), ms | 2.22 ± 0.50 | 1.25 ± 0.18 | <0.001 |
Adaptation index (A) | 71.4 ± 4.2 | 56.2 ± 6.7 | <0.001 |
Adaptation decay time constant (τa), ms | 29.5 ± 9.5 | 54.2 ± 33.8 | <0.05 |
Ri, MΩ | 349.7 ± 165.2 | 229.3 ± 73.1 | <0.05 |
τi, ms | 40.2 ± 10.53 | 21.8 ± 9.2 | <0.001 |
d1 | 0.84 ± 0.12 | 0.65 ± 0.13 | <0.001 |
dss | 0.57 ± 0.12 | 0.36 ± 0.12 | <0.001 |
Values are means ± SD. Significant differences between the RS and FS groups are indicated in P. RS, regular spiking; FS, fast spiking; AHP, afterhyperpolarization; SS, steady state; Ri, input resistance estimated by impedance amplitude; τi time constant estimated by impedance amplitude; d1, the power parameter d of the approximation of the f–I curve by f = (aI – b)d for the 1st instantaneous firing frequency; dss, for SS firing frequency.