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Article: Median and dorsal raphe neurons are not electrophysiologically identical.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Beck SG; Pan YZ; Akanwa AC; Kirby LG
J. Neurophysiol., 2004



TABLE 1.Cellular characteristics of neurons recorded from the ventromedial DR and MR
Area
RMP (mV)
Res (MΩ)
Tau (ms)
AHP amp (mV)
AHP t 1/2 (ms)
AHP dur (ms)
AP amp (mV)
AP dur (ms)
AP thresh (mV)
DR 5-HT (N = 33) –63 ± 1.7 637 ± 32 51 ± 3.0 16 ± 0.8 132 ± 5.5 338 ± 13 69 ± 1.4 2.0 ± 0.1 –22 ± 1.7
DR Non 5-HT (N = 16) –68 ± 1.5 531 ± 38 42 ± 2.6* 14 ± 1.0 117 ± 10 325 ± 25 63 ± 3.5 1.5 ± 0.1* –23 ± 2.4
MR 5-HT (N = 23) –66 ± 1.6 688 ± 35 44 ± 2.2‡ 20 ± 0.7‡ 137 ± 12 307 ± 22 72 ± 1.5 2.1 ± 0.1 –20 ± 1.9
MR Non-5-HT (N = 14)
–58 ± 2.8**
 432 ± 57†
 22 ± 2.1†
 15 ± 1.6†
 64 ± 12†
 178 ± 20†
 70 ± 2.0
1.5 ± 0.2†
 –27 ± 3.0†
Values are mean ± SE. *DR 5-HT different from DR non–5-HT: tau t = 2.1, P = 0.04; AP duration t = 3.5, P = 0.001. †MR 5-HT different from MR non–5-HT: RMP t = 2.6, P = 0.01, Res t = 4.0, P = 0.0003; tau t = 6.7, P = 0.00000009; AHP amplitude t = 3.3, P = 0.002; AHP t1/2 t = 4.6, P = 0.000005; AHP duration t = 4.8, P = 0.00003; AP duration t = 3.2, P = 0.003; AP threshold t = –2.2, P = 0.04. ‡DR 5-HT different from MR 5-HT: tau t = 2.2, P = 0.03, AHP amplitude t = –2.8, P = 0.008.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Dorsal Raphe Nucleus Serotonergic neuron resting membrane potential (mV) -63.0 ± 1.7 (33) -63.0 (mV) Data Table
Other Dorsal Raphe Nucleus Serotonergic neuron input resistance (MΩ) 637.0 ± 32.0 (33) 637.0 (MΩ) Data Table
Other Dorsal Raphe Nucleus Serotonergic neuron membrane time constant (ms) 51.0 ± 3.0 (33) 51.0 (ms) Data Table
Other Dorsal Raphe Nucleus Serotonergic neuron AHP amplitude (mV) 16.0 ± 0.8 (33) 16.0 (mV) Data Table
Other Dorsal Raphe Nucleus Serotonergic neuron AHP duration (ms) 132.0 ± 5.5 (33) 132.0 (ms) Data Table
Other Dorsal Raphe Nucleus Serotonergic neuron AHP duration (ms) 338.0 ± 13.0 (33) 338.0 (ms) Data Table
Other Dorsal Raphe Nucleus Serotonergic neuron spike amplitude (mV) 69.0 ± 1.4 (33) 69.0 (mV) Data Table
Other Dorsal Raphe Nucleus Serotonergic neuron spike width (ms) 2.0 ± 0.1 (33) 2.0 (ms) Data Table
Other Dorsal Raphe Nucleus Serotonergic neuron spike threshold (mV) -22.0 ± 1.7 (33) -22.0 (mV) Data Table
Other Dorsal Raphe Nucleus non-Serotonergic neuron resting membrane potential (mV) -68.0 ± 1.5 (16) -68.0 (mV) Data Table
Other Dorsal Raphe Nucleus non-Serotonergic neuron input resistance (MΩ) 531.0 ± 38.0 (16) 531.0 (MΩ) Data Table
Other Dorsal Raphe Nucleus non-Serotonergic neuron membrane time constant (ms) 42.0 ± 2.6 (16) 42.0 (ms) Data Table
Other Dorsal Raphe Nucleus non-Serotonergic neuron AHP amplitude (mV) 14.0 ± 1.0 (16) 14.0 (mV) Data Table
Other Dorsal Raphe Nucleus non-Serotonergic neuron AHP duration (ms) 117.0 ± 10.0 (16) 117.0 (ms) Data Table
Other Dorsal Raphe Nucleus non-Serotonergic neuron AHP duration (ms) 325.0 ± 25.0 (16) 325.0 (ms) Data Table
Other Dorsal Raphe Nucleus non-Serotonergic neuron spike amplitude (mV) 63.0 ± 3.5 (16) 63.0 (mV) Data Table
Other Dorsal Raphe Nucleus non-Serotonergic neuron spike width (ms) 1.5 ± 0.1 (16) 1.5 (ms) Data Table
Other Dorsal Raphe Nucleus non-Serotonergic neuron spike threshold (mV) -23.0 ± 2.4 (16) -23.0 (mV) Data Table
Other Medial Raphe Nucleus Serotonergic neuron resting membrane potential (mV) -66.0 ± 1.6 (23) -66.0 (mV) Data Table
Other Medial Raphe Nucleus Serotonergic neuron input resistance (MΩ) 688.0 ± 35.0 (23) 688.0 (MΩ) Data Table
Other Medial Raphe Nucleus Serotonergic neuron membrane time constant (ms) 44.0 ± 2.2 (23) 44.0 (ms) Data Table
Other Medial Raphe Nucleus Serotonergic neuron AHP amplitude (mV) 20.0 ± 0.7 (23) 20.0 (mV) Data Table
Other Medial Raphe Nucleus Serotonergic neuron AHP duration (ms) 137.0 ± 12.0 (23) 137.0 (ms) Data Table
Other Medial Raphe Nucleus Serotonergic neuron AHP duration (ms) 307.0 ± 22.0 (23) 307.0 (ms) Data Table
Other Medial Raphe Nucleus Serotonergic neuron spike amplitude (mV) 72.0 ± 1.5 (23) 72.0 (mV) Data Table
Other Medial Raphe Nucleus Serotonergic neuron spike width (ms) 2.1 ± 0.1 (23) 2.1 (ms) Data Table
Other Medial Raphe Nucleus Serotonergic neuron spike threshold (mV) -20.0 ± 1.9 (23) -20.0 (mV) Data Table
Other Medial Raphe Nucleus non-Serotonergic neuron resting membrane potential (mV) -58.0 ± 2.8 (14) -58.0 (mV) Data Table
Other Medial Raphe Nucleus non-Serotonergic neuron input resistance (MΩ) 432.0 ± 57.0 (14) 432.0 (MΩ) Data Table
Other Medial Raphe Nucleus non-Serotonergic neuron membrane time constant (ms) 22.0 ± 2.1 (14) 22.0 (ms) Data Table
Other Medial Raphe Nucleus non-Serotonergic neuron AHP amplitude (mV) 15.0 ± 1.6 (14) 15.0 (mV) Data Table
Other Medial Raphe Nucleus non-Serotonergic neuron AHP duration (ms) 64.0 ± 12.0 (14) 64.0 (ms) Data Table
Other Medial Raphe Nucleus non-Serotonergic neuron AHP duration (ms) 178.0 ± 20.0 (14) 178.0 (ms) Data Table
Other Medial Raphe Nucleus non-Serotonergic neuron spike amplitude (mV) 70.0 ± 2.0 (14) 70.0 (mV) Data Table
Other Medial Raphe Nucleus non-Serotonergic neuron spike width (ms) 1.5 ± 0.2 (14) 1.5 (ms) Data Table
Other Medial Raphe Nucleus non-Serotonergic neuron spike threshold (mV) -27.0 ± 3.0 (14) -27.0 (mV) Data Table