Table 2. Association with nociceptor markers and putative subunit composition of ASIC current types
| Type 1 | Type 2 | Type 3 | |
|---|---|---|---|
| The association between an ASIC current type and a given marker is indicated as the percentage of neurones positive for the given marker of the total number of neurones expressing this current type. *In control experiments (data not shown), the proportion of IB4-positive small-diameter neurones was 54% (n = 283). This factor was used to calculate from the data shown in Fig. 2D the fraction of IB4-binding neurones of the total population of neurones expressing a given ASIC current type. †From Fig. 3A, corresponding to the number of different populations of ASIC channels contributing to the current type; ‡based on the biophysical and pharmacological analysis; §concerning the main current component. | |||
| Association with markers (% of neurones) | |||
| TRPV1 current | 76 | 79 | 81 |
| AP with an inflection | 47 | 100 | 100 |
| IB4 binding* | 14 | 60 | 41 |
| Number of components in the activation curve† | 1 | ≥ 2 | 2 |
| Putative subunit composition‡ | ASIC1a homomultimers | ASIC2-containing heteromers | ASIC1a- and ASIC3-containing heteromers§ |
| Frequency (%) | 59 | 15 | 26 |