Article: Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells.

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Osorio N; Cathala L; Meisler MH; Crest M; Magistretti J; Delmas P
J. Physiol. (Lond.), 2010

Table 2. Intrinsic membrane properties and action potential (AP) characteristics measured in WT and Scn8a KO CG cells

	WT		Scn8a KO		P
	mean ± s.e.m.	n	mean ± s.e.m.	n	P
Statistical comparisons were made applying Student's two-tail t test for unpaired data.
Input capacitance (pF)	3.9 ± 0.2	23	3.9 ± 0.3	17	>0.05
Input conductance (pS)	0.7 ± 0.1	21	0.8 ± 0.1	15	>0.05
Resting membrane potential (mV)	−92.5 ± 1.6	11	−94.1 ± 1.3	13	>0.05
AP threshold (mV)	−42.4 ± 1	23	−42.8 ± 0.9	17	>0.05
AP overshoot (mV)	22.5 ± 2	23	21.2 ± 2	17	>0.05
AP rise time (ms)	0.42 ± 0.02	23	0.33 ± 0.01	16	<0.05
AP half-width (ms)	0.67 ± 0.02	23	0.51 ± 0.02	16	<0.05
Postspike AHP (mV)	−71.6 ± 0.7	23	−74.9 ± 0.8	17	<0.05

Inferred neuron-electrophysiology data values

Neuron Type	Ephys Prop	Extracted Value	Standardized Value	Content Source
Cerebellum granule cell	cell capacitance (pF)	3.9 ± 0.2 (23)	3.9 (pF)	Data Table
Cerebellum granule cell	resting membrane potential (mV)	-92.5 ± 1.6 (23)	-92.5 (mV)	Data Table
Cerebellum granule cell	spike threshold (mV)	-42.4 ± 1.0 (23)	-42.4 (mV)	Data Table
Cerebellum granule cell	spike peak (mV)	22.5 ± 2.0 (23)	22.5 (mV)	Data Table
Cerebellum granule cell	spike rise time (ms)	0.42 ± 0.02 (23)	0.42 (ms)	Data Table
Cerebellum granule cell	spike half-width (ms)	0.67 ± 0.02 (23)	0.67 (ms)	Data Table
Cerebellum granule cell	AHP voltage (mV)	-71.6 ± 0.7 (23)	-71.6 (mV)	Data Table