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Article: Electrophysiological evidence of monosynaptic excitatory transmission between granule cells after seizure-induced mossy fiber sprouting.

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Scharfman HE; Sollas AL; Berger RE; Goodman JH
J. Neurophysiol., 2003



TABLE 1.Parameters of unitary EPSPs


Pair No.

Amplitude [Base to Peak] (mV)

Time to Peak [Onset to Peak*] (ms)

Time to Peak [AP to Peak†] (ms)

10-90% Rise Time (ms)

Half Duration (ms)

Failure Rate (%)

1 (n = 9)
    Mean 1.74 3.72 5.89 2.90 17.07 59.1
    SE 0.52 1.51 1.50 1.13 21.87
2 (n = 10)
    Mean 2.20 3.68 5.53 2.53 14.90 68.8
    SE 1.11 1.18 1.59 0.74 9.69
3 (n = 10)
    Mean 1.90 4.10 5.59 2.77 12.91 52.6
    SE 0.40 1.80 0.89 0.79 16.09
4 (n = 7)
    Mean 1.73 5.58 6.43 3.39 14.22 78.0
    SE 0.80 2.41 2.69 1.22 15.94
5 (n = 11)
    Mean 1.76 4.35 5.86 2.31 19.00 61.5
    SE 0.65 1.37 1.94 0.39 14.20
6 (n = 8)
    Mean 2.17 3.22 5.04 2.07 11.33 71.4
    SE

0.40

1.56

2.00

0.79

10.75




Values are listed as mean ± SE and n = sample size. Characteristics of unitary excitatory postsynaptic potentials (EPSPs) from 6 pairs of monosynaptic connections between granule cells of rats with mossy fiber sprouting. Means are from 7 to 13 consecutive EPSPs that were evoked by presynaptic action potentials triggered at 1 Hz. Presynaptic action potentials were evoked by fixed amplitude current pulses at 1 Hz. Failures are excluded. Time to peak was measured from the end of the capacitative artifact of the presynaptic action potential to the peak of the unitary event (*) or from the peak of the presynaptic action potential to the peak of the unitary EPSP (†). For definitions of amplitude, rise-time and half-duration, see METHODS.

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