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Article: A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Reid G; Babes A; Pluteanu F
J. Physiol. (Lond.), 2002


Table 2

Action potentials and voltage-gated currents in cold-sensitive and cold-insensitive DRG neurones

Cold-sensitive n Cold-insensitive n P*
Diameter (μm) 18.8 ± 1.6 32 20.7 ± 2.2 60 <0.001
Action potential parameter:
 Resting potential (mV) −53.0 ± 7.0 21 −51.6 ± 5.0 38 n.s
 Amplitude (mV) 93.2 ± 13.6 21 89.3 ± 11.6 38 n.s.
 Duration at takeoff voltage (ms) 3.6 ± 1.5 21 89.3 ± 11.6 38 n.s.
 After-hyperpolarisation (AHP) (mV) 4.4 ± 2.9** 16 12. ± 4.7 38 <0.001
 AHP-hyperpolarisation (AHP) (mV) 100 ± 96** 13 112 ± 68 38 n.s.
 Number showing inflection 8/21(38%) 27/38(71%) <0.001 (X2test)
Voltage-gated currents:
 Ih amplitude (pA) 106 ± 79 33 71.4 ± 47 63 0.008
 Decay time constant of transient inward current (ms) 0.9 ± 0.2 32 2.3 ± 0.9 63 <0.0001
 Number expressing A-type K+ current 14/33(42%) 50/64(78%) <0.001 (X2 test)
 Cold-sensitive neurones only: Capsaicin-sensitive Capsaicin-insensitive
Ih amplitude (pA) 90.0 ± 55 14 191 ± 89 7 0.004
Action potential duration (ms) 31. ± 0.7 14 4.5 ± 2.2 7 0.04
  • * Student's unmpaired t test unless stated

  • ** AHP absent in 5 neurones and too small to measure duration in a further 3 neurones.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
DRG temperature cell cell diameter (μm) 18.8 ± 1.6 (32) 18.8 (um) Data Table
Dorsal root ganglion cell cell diameter (μm) 20.7 ± 2.2 (38) 20.7 (um) Data Table
DRG temperature cell resting membrane potential (mV) -53.0 ± 7.0 (32) -53.0 (mV) Data Table
Dorsal root ganglion cell resting membrane potential (mV) -51.6 ± 5.0 (38) -51.6 (mV) Data Table
DRG temperature cell spike amplitude (mV) 93.2 ± 13.6 (32) 93.2 (mV) Data Table
Dorsal root ganglion cell spike amplitude (mV) 89.3 ± 11.6 (38) 89.3 (mV) Data Table
DRG temperature cell AHP amplitude from resting 4.4 ± 2.9 (32) 4.4 (mV) Data Table
Dorsal root ganglion cell AHP amplitude from resting 12.0 ± 4.7 (38) 12.0 (mV) Data Table