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Article: A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction.

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Reid G; Babes A; Pluteanu F
J. Physiol. (Lond.), 2002


Table 4

Effects of nerve growth factor on cold responsiveness and the cold-activated current

NGF n noNGF n P*
ΔFIF0 on colling 0.40 ± 0.16 205 0.33 ± 0.16 50 0.007
Threshold temperature for increase in [Ca2+] 30.5 ± 3.8 205 27.9 ± 3.5 50 <0.001
Threshold temperature for increase in [Ca2+] in 100 μm (-) menthol (°C) 35.4 ± 4.0 26 29.9 ± 8.0 12 0.008
Cold-induced depolarisation at 18°C(mV) 28.9 ± 8.1 45 20.4 ± 8.3 16 <0.001
Depolarisation threshold (°C) 31.9 ± 8.1 46 28.3 ± 3.8 13 0.04
Cold-actived current at 18 ° (pA) 137 ± 90 63 60 ± 52 15 0.002
Cold-activated current threshold (°C) 31.5 ± 2.7 62 28.6 ± 2.9 13 <0.001
  • * student's unpaired t test.


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