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Article: Altered synaptic and non-synaptic properties of CA1 pyramidal neurons in Kv4.2 knockout mice.

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Andrásfalvy BK; Makara JK; Johnston D; Magee JC
J. Physiol. (Lond.), 2008


Table 1. Intrinsic membrane and spike properties of CA1 pyramidal cells from WT and KO mice in control solution and during bicuculline administration

WT KO
Control Bicuculline Control Bicucculine
Results of statistical analysis are indicated with different symbols: *P < 0.05, *WT-KO, †P < 0.05, †WT-KO+Bic.
Vrest (mV) −57.52 ± 0.52  −58.58 ± 0.70  −59.36 ± 0.79  −57.35 ± 0.74 
(n = 21) (n = 12) (n = 19) (n = 14)
Vthres (mV) −53.51 ± 0.48† −52.39 ± 0.53  −52.39 ± 0.54  −51.04 ± 0.50 
(n = 15) (n = 10) (n = 16) (n = 10)
Amplitude of 1st spike (mV)  77.63 ± 2.14* 76.96 ± 4.73 87.86 ± 2.05 80.43 ± 5.87
(n = 17) (n = 8) (n = 15) (n = 11)
Onset time of 1st spike (ms) 41.52 ± 4.27 41.07 ± 9.46 45.63 ± 9.23  55.69 ± 16.67
(n = 21) (n = 8) (n = 19) (n = 14)
Steady-state (MΩ) 63.34 ± 2.30 63.89 ± 0.32 63.00 ± 1.54 67.75 ± 2.44
(n = 21) (n = 12) (n = 19) (n = 14)
Peak (MΩ) 72.53 ± 2.08 76.92 ± 4.31 73.02 ± 1.95 80.58 ± 3.06
(n = 21) (n = 12) (n = 19) (n = 14)

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell spike threshold (mV) -53.51 ± 0.48 (21) -53.51 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 77.63 ± 2.14 (21) 77.63 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -57.52 ± 0.52 (21) -57.52 (mV) Data Table
Hippocampus CA1 pyramidal cell first spike latency (ms) 41.52 ± 4.27 (21) 41.52 (ms) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 63.34 ± 2.3 (21) 63.34 (MΩ) Data Table