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Article: Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation.

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Derchansky M; Jahromi SS; Mamani M; Shin DS; Sik A; Carlen PL
J. Physiol. (Lond.), 2008


Table 2. The calculated chloride equilibrium potential (ECl) and the observed Erev values during the preictal state in pyramidal cells and interneurons

A. Normal chloride High chloride Perforated patch
Calculated ECl (mV) −65.0 −30.0 −81.0 to −60.0
Evoked EGABAA-Muscimol (mV) −72.0 ± 4.0 (normal ACSF)
−64.0 ± 3.0 (low Mg2+ ACSF – soma, interictal)
Table. −55.0 ± 5.0 (low Mg2+ ACSF – dendrite, interictal)
B. Observed Erev of PSP (mV)
Preictalh Preictald
Normal chloride High chloride Perforated patch Normal chloride High chloride Perforated patch
A. ECl was calculated independently of the neuron being recorded as this value depends only on the chloride concentration in the patch pipette (top row). The values of evoked PSP potentials from focally applied muscimol on the soma or dendrites of CA1 neurons in normal ACSF and during the interictal state in low Mg2+ ACSF were obtained. Note the more depolarized values in the dendrites. B. Observed Erev values during the preictalh and preictald states in the three neuronal groups with three recording solutions (normal chloride, 5 mm; high chloride, 30 mm; perforated patch). *Significant differences in values between the calculated ECl and observed Erev values during the preictalh state. †Significant difference in values between the three recording pipette solutions across the same neuronal group during the preictalh state. ‡Significant difference between Erev values during the preictalh state and Erev values in the preictald state. All results are shown as mean ± s.e.m.
Pyramidal cell −58.0 ± 5.0†  −37.0 ± 3.0† −70.0 ± 4.0† −30.0 ± 6.0‡  −7.0 ± 3.0‡  −2.0 ± 10.0‡
FS interneuron −44.0 ± 4.0*† −33.0 ± 4.0† −55.0 ± 6.0† +33.0 ± 5.0‡ +29.0 ± 6.0‡ +31.0 ± 11.0‡
Non-FS interneuron −45.0 ± 4.0*† −32.0 ± 3.0† −58.0 ± 6.0† +29.0 ± 6.0‡ +21.0 ± 4.0‡ +40.0 ± 11.0‡

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Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source