Lobule III–V (n = 37) | Lobule X (n = 49) | |||||
---|---|---|---|---|---|---|
Tonic firing | Complex bursting | Tonic firing | Complex bursting | Initial bursting | Gap firing | |
(n = 25) | (n = 12) | (n = 13) | (n = 11) | (n = 10) | (n = 15) | |
Statistical significance was examined by unpaired t test or one-way ANOVA with post hoc Scheffe's test. n, number of observations. Statistical comparison of parameters was first performed in all neurons irrespective of firing pattern between lobules III–V and X. *P < 0.05 between Purkinje neurons of all firing patterns in lobule III–V and those in lobule X. Then, statistical comparison was done among tonic firing neurons in lobule III–V, tonic firing neurons in lobule X, and gap firing neurons in lobule X. †P < 0.05 between tonic firing neurons in lobule III–V and tonic firing neurons in lobule X. †P < 0.05 between tonic firing neurons in lobule III–V and gap firing neurons in lobule X. §P < 0.05 between tonic firing neurons in lobule X and gap firing neurons in lobule X. ¶P < 0.05 between complex bursting neurons in lobule III–V and complex bursting neurons in lobule X. | ||||||
Input resistance (MΩ)* | 101.9 ± 6.4 | 104.2 ± 6.7 | 75.6 ± 4.2† | 96.2 ± 15.5 | 87.8 ± 4.4 | 101.8 ± 4.8§ |
Sag amplitude (mV)* | 16.4 ± 0.8 | 18.4 ± 1.5 | 21.0 ± 1.3† | 21.8 ± 0.7¶ | 24.1 ± 1.9 | 23.2 ± 1.3† |
Membrane capacitance (pF)* | 543.7 ± 32.9 | 596.1 ± 34.0 | 661.8 ± 36.2† | 721.9 ± 46.9¶ | 681.1 ± 46.8 | 618.9 ± 50.9 |
AP threshold (mV)* | −45.1 ± 0.5 | −43.6 ± 1.2 | −38.0 ± 0.9† | −33.1 ± 1.1¶ | −39.7 ± 1.7 | −28.5 ± 1.3‡§ |
Rheobase current (pA)* | 112.6 ± 13.8 | 116.3 ± 9.6 | 295.4 ± 28.4† | 246.7 ± 46.6¶ | 280.0 ± 32.6 | 283.3 ± 34.4† |
AP amplitude (mV)* | 77.3 ± 1.3 | 74.6 ± 2.2 | 68.6 ± 2.0† | 56.0 ± 1.8¶ | 64.4 ± 1.3 | 37.7 ± 3.1‡§ |
Maximal dV/dt, upstroke (V s−1)* | 405.9 ± 12.5 | 392.6 ± 17.4 | 314.1 ± 14.3† | 245.0 ± 9.0¶ | 283.2 ± 13.5 | 114.4 ± 16.5‡§ |
AHP (mV) | 12.2 ± 0.6 | 10.7 ± 0.6 | 11.4 ± 1.1 | 10.5 ± 1.7 | 13.5 ± 1.5 | 19.6 ± 0.9‡§ |
Article: Lobule-specific membrane excitability of cerebellar Purkinje cells.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Kim CH; Oh SH; Lee JH; Chang SO; Kim J; Kim SJ J. Physiol. (Lond.), 2012