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Article: Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons.

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Jones DL; Howard MA; Stanco A; Rubenstein JL; Baraban SC
J. Neurophysiol., 2011


Table 1.

Dlx1 knockout interneurons are functionally immature at P9–12

FF (2×T) Rin fAHP1 AP Width Vm
WT 15.08 ± 1.69 291.35 ± 18.13 19.50 ± 0.81 1.54 ± 0.04 −56.59 ± 0.95
Dlx1 knockout 19.51 ± 2.02 359.16 ± 27.99* 21.62 ± 1.28 1.67 ± 0.08 −51.57 ± 1.25*
  • Shown are mean values ± SE for firing frequency (FF) at twice the firing threshold (2×T), input resistance (Rin), amplitude of fast after hyperpolarization (fAHP1), action potential (AP) width, and resting membrane potential (Vm). Recordings were obtained from hippocampal CA1 interneurons in postnatal days 9–12 (P9–12) wild-type (WT) and mutant mice.

  • * P < 0.05, Student's t-test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Hippocampus CA1 GABAergic Interneurons firing frequency 15.08 ± 1.69 15.08 (Hz) Data Table
Other Hippocampus CA1 GABAergic Interneurons input resistance 291.35 ± 18.13 291.35 (MΩ) Data Table
Other Hippocampus CA1 GABAergic Interneurons fast AHP amplitude 19.5 ± 0.81 19.5 (mV) Data Table
Other Hippocampus CA1 GABAergic Interneurons spike width 1.54 ± 0.04 1.54 (ms) Data Table
Other Hippocampus CA1 GABAergic Interneurons resting membrane potential -56.59 ± 0.95 -56.59 (mV) Data Table