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Article: Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons.

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Muroi Y; Ru F; Kollarik M; Canning BJ; Hughes SA; Walsh S; Sigg M; Carr MJ; Undem BJ
J. Physiol. (Lond.), 2011


Table 2. Boltzmann parameters of the conductance–voltage relationships

n Vm z
Vm and z values are mean ± SEM. Statistical comparisons were made using two-way ANOVAs (shRNA treatment and TTX application factors) followed by Bonferroni's post hoc tests. An asterisk denotes a significant difference caused by TTX treatment (*P < 0.01). A † denotes a difference (P < 0.01) in Vm between control and NaV1.7 shRNA treated neurons.
Before TTX (control) 14 −32.17 ± 1.53 7.0 ± 0.89
After TTX (control) 14  −16.4 ± 1.92* 5.8 ± 0.24
Before TTX (NaV1.7 shRNA) 17  −23.2 ± 1.87† 5.2 ± 0.36
After TTX (NaV1.7 shRNA) 17  −14.8 ± 1.04* 5.8 ± 0.39

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source