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Article: Carbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions.

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Rouach N; Segal M; Koulakoff A; Giaume C; Avignone E
J. Physiol. (Lond.), 2003


Table 3

Glutamate-induced calcium responses in neurons

Co-cultures Control 100 μm CBX Wash Control 100 μm GZA
Baseline (F0) (a.u.) 899 ± 45 971 ± 46 921 ± 76 870 ± 32 848 ± 36
Peak normalised amplitude (ΔF/F0) 190 ± 20 180 ± 20 160 ± 10 220 ± 10 230 ± 10
Rise time (s) 1.48 ± 0.16 1.57 ± 0.11 1.38 ± 0.17 0.98 ± 0.12 1.08 ± 0.13
Half-decay time (s) 6.48 ± 0.25 9.69 ± 1.18** 7.55 ± 0.68 6.38 ± 0.22 6.58 ± 0.20

Enriched neuronal cultures Control 100 μm CBX Wash

Baseline (F0) (a.u.) 810 ± 28 808 ± 32 802 ± 28
Peak normalised amplitude (ΔF/F0) 200 ± 10 190 ± 10 180 ± 10
Rise time (s) 0.79 ± 0.05 0.80 ± 0.05 0.76 ± 0.07
Half-decay time (s) 7.25 ± 0.58 6.38 ± 0.46 6.03 ± 0.61
  • Data are expressed as mean ±s.e.m. and were obtained from 4 and 5 independent experiments in co-cultures and enriched neuronal cultures, respectively. Neurons were recorded before (control), after perfusion with carbenoxolone (CBX, 100 μm, 10 min) and wash or after glycyrrhizic acid (GZA, 100 μm, 10 min). ANOVA followed by post hoc Bonferroni's multiple comparison (CBX) or Student's unpaired t test (GZA) were applied for statistical analysis

  • ** P < 0.01.


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