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Article: Carbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions.

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Rouach N; Segal M; Koulakoff A; Giaume C; Avignone E
J. Physiol. (Lond.), 2003


Table 4

Basic membrane properties and action potential characteristics in neurons

Control 100 μm CBX Wash
Resting membrane potential (mV) −58.9 ± 2.2 −58.4 ± 3.1 −59.2 ± 2.7(12)
Input resistance (MΩ) 348.5 ± 100.6 186.5 ± 44.3* 298.8 ± 63.2(6)
AP amplitude (mV) 82.8 ± 5 83 ± 6 82.3 ± 6(7)
AP threshold (mV) −30.4 ± 1.9 −23.8 ± 2.9* −29.3 ± 2.1(7)
Elicited AP s−1 6.6 ± 0.5 0.8 ± 0.5** 4.4 ± 0.5(7)

  • Data are expressed as mean ±s.e.m. and are sampled from neurons recorded before (Control), after perfusion with carbenoxolone (CBX, 100 μm, 10 min) and after CBX wash (Wash, 10 min). ANOVA followed by post hoc Bonferroni's multiple comparison was applied for statistical analysis

  • ↵* P < 0.05,

  • ↵** P < 0.01.

  • Numbers in parentheses are the number of cells. AP, action potential.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Hippocampus uncharacterized cell resting membrane potential (mV) -58.9 ± 2.2 -58.9 (mV) Data Table
Other Hippocampus uncharacterized cell input resistance (MΩ) 348.5 ± 100.6 348.5 (MΩ) Data Table
Other Hippocampus uncharacterized cell spike amplitude (mV) 82.8 ± 5.0 82.8 (mV) Data Table
Other Hippocampus uncharacterized cell spike threshold (mV) -30.4 ± 1.9 -30.4 (mV) Data Table