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Article: Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor-.

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J. Physiol. (Lond.), 2011


Table 1. The passive membrane properties of GAD67+ GABAergic neurons in spinal lamina II

Recorded with normal pipette solution Recorded with SB202190 in pipette
Tonic firing Initial bursting P Delayed firing Single spike Tonic firing Initial bursting P
Values are mean ± SEM. P value in the column: tonic vs. initial bursting neurons recorded with the same pipette solution. P value in parentheses: recorded with vs. without SB202190 in pipette solution for the same type of neurons. *Student's t test, †Wilcoxon rank-sum test. Cm, membrane capacitance; Rin, input resistance; RMP, resting membrane potential; CT, current threshold for action potential.
Cm (pF) 42.1 ± 2.5 42.0 ± 5.4 0.98* 37.3 ± 10.6 19.0 43.5 ± 3.0 42.7 ± 2.2 0.92*
& 41.2 (P = 0.77*) (P = 0.58†)
Rin (MΩ) 458.7 ± 47.4 350.8 ± 62.0 0.16† 499.4 ± 58.2 337.9 449.0 ± 35.2 380.2 ± 43.6 0.32*
& 218.7 (P = 0.47†) (P = 0.34†)
RMP (mV) −50.7 ± 1.1 −52.8 ± 2.4 0.35* −61.3 ± 1.9 −42.0 −52.7 ± 1.4 −53.6 ± 2.6 0.75*
(P = 0.26*) (P = 0.85*)
CT (pA) 39.7 ± 4.8 48.5 ± 6.5 0.14† 76.7 ± 38.5 100.0 34.8 ± 3.1 42.9 ± 5.2 0.21†
& 60.0 (P = 0.66†) (P = 0.57*)
N 32 13 3 2 23 7

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Spinal cord ventral horn interneuron II input resistance (MΩ) 458.7 ± 47.4 458.7 (MΩ) Data Table
Spinal cord ventral horn interneuron II cell capacitance (pF) 42.1 ± 2.5 42.1 (pF) Data Table
Spinal cord ventral horn interneuron II resting membrane potential (mV) -50.7 ± 1.1 -50.7 (mV) Data Table