Pre-DHPG | DHPG | 30-min Wash | 60-min Wash | |
---|---|---|---|---|
sAHP amp, mV | −7.1 ± 0.3 | −0.6 ± 0.2* | −2.8 ± 0.5* | −3.8 ± 0.5* |
n | 17 | 17 | 12 | 10 |
mAHP amp, mV | −4.6 ± 0.3 | −1.3 ± 0.5* | −4.0 ± 0.4* | −3.9 ± 0.4* |
n | 11 | 11 | 11 | 10 |
No. of spikes | 7.8 ± 0.6 | 15.5 ± 0.7* | 10.9 ± 1.1* | 9.4 ± 1.2 |
n | 15 | 15 | 10 | 6 |
R in, MΩ | 61.1 ± 3.5 | 67.2 ± 4.1* | 60.0 ± 5.2 | 58.8 ± 6.2 |
n | 17 | 17 | 12 | 10 |
I hold, nA | 0.07 ± 0.02 | −0.03 ± 0.02* | 0.04 ± 0.03* | 0.07 ± 0.03 |
n | 17 | 17 | 12 | 10 |
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Data are raw (non-normalized) values and are of the form: means ± SE. n are number of data sample. All data are from experiments performed in the absence of DMSO with the exception of the mAHP for which data from experiments performed in the presence and absence of DMSO have been pooled. sAHP, slow afterhyperpolarization; mAHP, medium afterhyperpolarization; R in, input resistance; I hold, holding current.
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↵* Indicates a significant difference from pre-DHPG (baseline) values (P < 0.05, paired Student's t-test).