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Article: Group I mGluRs increase excitability of hippocampal CA1 pyramidal neurons by a PLC-independent mechanism.

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Ireland DR; Abraham WC
J. Neurophysiol., 2002


Table 1.

Effects of DHPG on cell parameters

Pre-DHPG DHPG 30-min Wash 60-min Wash
sAHP amp, mV −7.1  ± 0.3 −0.6  ± 0.2* −2.8  ± 0.5* −3.8  ± 0.5*
n 17 17 12 10
mAHP amp, mV −4.6  ± 0.3 −1.3  ± 0.5* −4.0  ± 0.4* −3.9  ± 0.4*
n 11 11 11 10
No. of spikes 7.8  ± 0.6 15.5  ± 0.7* 10.9  ± 1.1* 9.4  ± 1.2
n 15 15 10 6
R in, MΩ 61.1  ± 3.5 67.2  ± 4.1* 60.0  ± 5.2 58.8  ± 6.2
n 17 17 12 10
I hold, nA 0.07 ± 0.02 −0.03 ± 0.02* 0.04 ± 0.03* 0.07 ± 0.03
n 17 17 12 10
  • Data are raw (non-normalized) values and are of the form: means ± SE. n are number of data sample. All data are from experiments performed in the absence of DMSO with the exception of the mAHP for which data from experiments performed in the presence and absence of DMSO have been pooled. sAHP, slow afterhyperpolarization; mAHP, medium afterhyperpolarization; R in, input resistance; I hold, holding current.

  • *  Indicates a significant difference from pre-DHPG (baseline) values (P < 0.05, paired Student's t-test).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell medium AHP amplitude (mV) -4.6 ± 0.3 (17) 4.6 (mV) Data Table
Hippocampus CA1 pyramidal cell slow AHP amplitude (mV) -7.1 ± 0.3 (17) 7.1 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 61.1 ± 3.5 (17) 61.1 (MΩ) Data Table
Hippocampus CA1 pyramidal cell rheobase (nA) 0.07 ± 0.02 (17) 70.0 (pA) Data Table