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Article: NKCC1 cotransporter inactivation underlies embryonic development of chloride-mediated inhibition in mouse spinal motoneuron.

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Delpy A; Allain AE; Meyrand P; Branchereau P
J. Physiol. (Lond.), 2008


Table 1. Ontogenic evolution of corrected resting membrane potential (Vrest) and spike threshold, membrane resistance (Rin) and capacitance (Cm) in lumbar spinal motoneurons (means ± s.e.m.)

Developmental stages: E13.5 E14.5 E15.5 E16.5 E17.5 E18.5 P0
Spike threshold (mV) −43.2 ± 2.7 −41.3 ± 1.6 −41.5 ± 1.8 −41.6 ± 2.0 −43.1 ± 0.7 −40.8 ± 2.6 −37.8 ± 0.8
(n = 6) (n = 13) (n = 9) (n = 8) (n = 8) (n = 4) (n = 12)
Vrest (mV) −55.4 ± 1.3 −64.8 ± 1.8 −60.4 ± 5.4 −65.0 ± 1.8 −69.1 ± 1.2 −66.3 ± 1.5 −70.2 ± 1.0
(n = 19) (n = 6) (n = 13) (n = 16) (n = 6) (n = 18) (n = 13)
Rin (MΩ) 945 ± 96 815 ± 98 383 ± 130 128 ± 34 146 ± 23 69.4 ± 11.1 41.4 ± 11.4
(n = 12) (n = 16) (n = 16) (n = 7) (n = 13) (n = 5) (n = 7)
Cm (pF) 29.5 ± 3.6 37.5 ± 2.6 61.2 ± 7.7 128.3 ± 19.4 121.3 ± 12.1 158.2 ± 24.8 205.5 ± 15.1
(n = 14) (n = 16) (n = 6) (n = 7) (n = 12) (n = 5) (n = 8)

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Spinal cord ventral horn motor neuron alpha resting membrane potential (mV) -55.4 ± 1.3 -- Data Table
Spinal cord ventral horn motor neuron alpha spike threshold (mV) -43.2 ± 2.7 -- Data Table
Spinal cord ventral horn motor neuron alpha input resistance (MΩ) 945.0 ± 96.0 -- Data Table
Spinal cord ventral horn motor neuron alpha cell capacitance (pF) 29.5 ± 3.6 -- Data Table