Article: NKCC1 cotransporter inactivation underlies embryonic development of chloride-mediated inhibition in mouse spinal motoneuron.
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Delpy A; Allain AE; Meyrand P; Branchereau P
J. Physiol. (Lond.), 2008
Table 1. Ontogenic evolution of corrected resting membrane potential (Vrest) and spike threshold, membrane resistance (Rin) and capacitance (Cm) in lumbar spinal motoneurons (means ±
s.e.m.)
Developmental stages: |
E13.5 |
E14.5 |
E15.5 |
E16.5 |
E17.5 |
E18.5 |
P0 |
Spike threshold (mV) |
−43.2 ± 2.7 |
−41.3 ± 1.6 |
−41.5 ± 1.8 |
−41.6 ± 2.0 |
−43.1 ± 0.7 |
−40.8 ± 2.6 |
−37.8 ± 0.8 |
(n
= 6)
|
(n
= 13)
|
(n
= 9)
|
(n
= 8)
|
(n
= 8)
|
(n
= 4)
|
(n
= 12)
|
Vrest (mV)
|
−55.4 ± 1.3 |
−64.8 ± 1.8 |
−60.4 ± 5.4 |
−65.0 ± 1.8 |
−69.1 ± 1.2 |
−66.3 ± 1.5 |
−70.2 ± 1.0 |
(n
= 19)
|
(n
= 6)
|
(n
= 13)
|
(n
= 16)
|
(n
= 6)
|
(n
= 18)
|
(n
= 13)
|
Rin (MΩ)
|
945 ± 96 |
815 ± 98 |
383 ± 130 |
128 ± 34 |
146 ± 23 |
69.4 ± 11.1 |
41.4 ± 11.4 |
(n
= 12)
|
(n
= 16)
|
(n
= 16)
|
(n
= 7)
|
(n
= 13)
|
(n
= 5)
|
(n
= 7)
|
Cm (pF)
|
29.5 ± 3.6 |
37.5 ± 2.6 |
61.2 ± 7.7 |
128.3 ± 19.4 |
121.3 ± 12.1 |
158.2 ± 24.8 |
205.5 ± 15.1 |
(n
= 14)
|
(n
= 16)
|
(n
= 6)
|
(n
= 7)
|
(n
= 12)
|
(n
= 5)
|
(n
= 8)
|
Inferred neuron-electrophysiology data values