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Article: Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice.

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Klapstein GJ; Fisher RS; Zanjani H; Cepeda C; Jokel ES; Chesselet MF; Levine MS
J. Neurophysiol., 2001


Table 1.

Passive and active membrane properties

WT R6/2-Presymptomatic WT R6/2-Symptomatic
Passive membrane properties
 RMP, mV −81.0  ±  1.7 (10) −80.5  ±  1.1 (21) −80.2  ±  1.3 (18) −67.3  ±  2.5 (19)1-165
R in, MΩ 26.7  ±  2.8 (10) 42.5  ±  3.8 (20)1-165 33.7  ±  3.0 (14) 48.0  ±  5.2 (18)1-165
 τ, ms 15.6  ±  3.2 (10) 16.6  ±  2.8 (21) 17.6  ±  2.8 (18) 11.0  ±  1.5 (20)*
AP properties
 Threshold, mV −43.9  ±  6.1 (8) −41.4  ±  6.1 (19) −48.9  ±  2.2 (12) −49.1  ±  2.9 (10)
 Amplitude, mV 64.3  ±  3.1 (8) 63.2  ±  1.9 (19) 60.8  ±  1.5 (13) 57.6  ±  2.6 (10)
 Half amplitude duration, ms 0.85  ±  0.03 (8) 0.82  ±  0.02 (19) 0.77  ±  0.03 (14) 0.82  ±  0.05 (10)
 Maximum rise slope, mV/ms 248.9  ±  19.7 (8) 247.6  ±  15.4 (19) 228.5  ±  12.9 (13) 197.8  ±  17.2 (10)
 Maximum decay slope, mV/ms −85.5  ±  5.6 (8) −88.7  ±  3.9 (19) −98.1  ±  3.4 (13) −84.3  ±  5.5 (10)*
 AHP amplitude, mV 15.5  ±  1.0 (8) 15.0  ±  0.6 (19) 12.7  ±  0.9 (13) 14.1  ±  1.8 (10)
 Rheobase, nA 0.70  ±  0.07 (7) 0.48  ±  0.03 (17)1-160 0.51  ±  0.04 (12) 0.40  ±  0.09 (7)1-160
Action potential trains
 Number APs/Train 1-a 11.0  ±  1.4 (7) 10.5  ±  0.9 (19) 13.2  ±  1.2 (12) 8.5  ±  1.1 (10)*
 Shortest interval, ms 20.2  ±  1.6 (7) 21.0  ±  1.0 (18) 20.2  ±  1.5 (13) 11.8  ±  1.3 (10)1-165
  • Values are means ± SE. Group n is in parentheses. WT, wild type; RMP, resting membrane potential; AHP, after hyperpolarization.

  • F1-a  Number of action potentials (APs) counted on the third trace exhibiting APs.

  • *P < 0.05,

  • F1-160P< 0.01,

  • F1-165P < 0.001.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum medium spiny neuron input resistance (MΩ) 26.7 ± 2.8 (10) 26.7 (MΩ) Data Table
Neostriatum medium spiny neuron input resistance (MΩ) 33.7 ± 3.0 (14) 33.7 (MΩ) Data Table
Neostriatum medium spiny neuron membrane time constant (ms) 15.6 ± 3.2 (10) 15.6 (ms) Data Table
Neostriatum medium spiny neuron membrane time constant (ms) 17.6 ± 2.8 (18) 17.6 (ms) Data Table
Neostriatum medium spiny neuron spike threshold (mV) -43.9 ± 6.1 (8) -43.9 (mV) Data Table
Neostriatum medium spiny neuron spike threshold (mV) -48.9 ± 2.2 (12) -48.9 (mV) Data Table
Neostriatum medium spiny neuron spike amplitude (mV) 64.3 ± 3.1 (8) 64.3 (mV) Data Table
Neostriatum medium spiny neuron spike amplitude (mV) 60.8 ± 1.5 (13) 60.8 (mV) Data Table
Neostriatum medium spiny neuron spike half-width (ms) 0.85 ± 0.03 (8) 0.85 (ms) Data Table
Neostriatum medium spiny neuron spike half-width (ms) 0.77 ± 0.03 (14) 0.77 (ms) Data Table
Neostriatum medium spiny neuron spike max rise slope (mV/ms) 248.9 ± 19.7 (8) 248.9 (mV/ms) Data Table
Neostriatum medium spiny neuron spike max rise slope (mV/ms) 228.5 ± 12.9 (13) 228.5 (mV/ms) Data Table
Neostriatum medium spiny neuron spike max decay slope (mV/ms) -85.5 ± 5.6 (8) 85.5 (mV/ms) Data Table
Neostriatum medium spiny neuron spike max decay slope (mV/ms) -98.1 ± 3.4 (13) 98.1 (mV/ms) Data Table
Neostriatum medium spiny neuron AHP amplitude (mV) 15.5 ± 1.0 (8) 15.5 (mV) Data Table
Neostriatum medium spiny neuron AHP amplitude (mV) 12.7 ± 0.9 (13) 12.7 (mV) Data Table
Neostriatum medium spiny neuron rheobase (nA) 0.7 ± 0.07 (7) 700.0 (pA) Data Table
Neostriatum medium spiny neuron rheobase (nA) 0.51 ± 0.04 (12) 510.0 (pA) Data Table
Neostriatum medium spiny neuron resting membrane potential (mV) -81.0 ± 1.7 (10) -81.0 (mV) Data Table
Neostriatum medium spiny neuron resting membrane potential (mV) -80.2 ± 1.3 (18) -80.2 (mV) Data Table