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Article: Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice.

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Klapstein GJ; Fisher RS; Zanjani H; Cepeda C; Jokel ES; Chesselet MF; Levine MS
J. Neurophysiol., 2001


Table 2.

Synaptic response properties

WT R6/2-Presymptomatic WT R6/2-Symptomatic
Maximum amplitude, mV 24.6  ±  1.8 (7) 24.6  ±  1.8 (17) 20.4  ±  2.8 (11) 22.1  ±  3.2 (4)
Amplitude, mV 2-a 7.9  ±  0.8 (10) 7.7  ±  0.6 (20) 7.1  ±  0.7 (16) 7.7  ±  1.0 (9)
Half amplitude duration 9.3  ±  0.7 (10) 10.5  ±  0.7 (14) 9.3  ±  0.7 (14) 10.5  ±  1.4 (9)
Area, mV × ms 99.7  ±  10.7 (10) 109.6  ±  12.1 (14) 91.0  ±  6.5 (14) 117.6  ±  19.5 (9)
10–90 Rise Time, mV/ms 2.9  ±  0.2 (10) 2.9  ±  0.2 (20) 2.6  ±  0.2 (16) 3.3  ±  0.3 (9)*
Decay τ, ms 6.1  ±  0.4 (10) 7.4  ±  0.7 (14) 7.2  ±  0.9 (14) 7.4  ±  1.6 (8)
Amplitude at 45 ms, mV 0.52  ±  0.28 (10) 0.54  ±  0.23 (14) 0.19  ±  0.18 (14) 0.99  ±  0.16 (8)2-160
PPF 1.23  ±  0.05 (10) 1.15  ±  0.08 (14)2-160 1.32  ±  0.05 (14) 1.03  ±  0.05 (7)2-160

  • Values are means ± SE. Group n is in parentheses. PPF, paired pulse facilitation.

  • ↵F2-a  Amplitude of response used for analysis of excitatory postsynaptic potentials.

  • ↵*  P < 0.05,

  • ↵F2-160  P< 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source