Article: Repeated cocaine administration increases voltage-sensitive calcium currents in response to membrane depolarization in medial prefrontal cortex pyramidal neurons.

Table 1.

Repeated cocaine administration altered Ca⁺² plateau potentials in mPFC pyramidal neurons after both 3 d and 2-3 weeks of withdrawal

	Saline	Cocaine
3 d of withdrawal
Number of neurons	20	21
Current to generate Ca²⁺ spikes (nA)	0.63 ± 0.05	0.65 ± 0.03
Spike threshold (mV)	−20.19 ± 0.67	−20.54 ± 0.81
Spike amplitude (mV)	64.02 ± 0.96	64.74 ± 0.93
Spike duration — one-half amplitude (ms)	697 ± 43	808 ± 26^*
Spike duration, step 1 (ms)	1349 ± 125	1938 ± 131^*
Spike duration, step 2 (ms)	681 ± 95	640 ± 101
Whole spike duration (ms)	2002 ± 147	2578 ± 89^*
Spike area, step 1	110,629 ± 9616	151,601 ± 8310^*
Spike area, step 2	18,209 ± 2853	16,855 ± 3088
Whole spike area	126,230 ± 9946	168,456 ± 6849^*
2-3 weeks of withdrawal
Number of neurons	15	12
Current to generate Ca²⁺ spikes (nA)	0.46 ± 0.04	0.41 ± 0.02
Spike threshold (mV)	−22.73 ± 0.75	−23.69 ± 0.73
Spike amplitude (mV)	69.03 ± 1.27	75.15 ± 1.05^*
Spike duration — one-half amplitude (ms)	695 ± 60	885 ± 46^*
Spike duration, step 1 (ms)	1282 ± 141	1661 ± 68^*
Spike duration, step 2 (ms)	664 ± 50	787 ± 71
Whole spike duration (ms)	1945 ± 163	2448 ± 83^*
Spike area, step 1	103,047 ± 11,061	137,542 ± 5756^*
Spke area, step 2	17,084 ± 1897	20,494 ± 2405
Whole spike area	120,131 ± 11,640	158,036 ± 5542^*

The properties of Ca²⁺ plateau potentials, measured by whole-cell current-clamp recordings, of mPFC pyramidal neurons from brain slices from saline- and cocaine-pretreated rats are shown. Values represent the mean ± SEM for the number of neurons indicated (^*p<0.05; Student's t test compared with the saline group).

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Neocortex pyramidal cell layer 5-6	Medial Prefrontal Cortex Layer V/VI Pyramidal Neuron	spike threshold (mV)	-20.19 ± 0.67	-20.19 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	Medial Prefrontal Cortex Layer V/VI Pyramidal Neuron	spike amplitude (mV)	64.02 ± 0.96	64.02 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	Medial Prefrontal Cortex Layer V/VI Pyramidal Neuron	spike half-width (ms)	697.0 ± 43.0	--	Data Table
Neocortex pyramidal cell layer 5-6	Medial Prefrontal Cortex Layer V/VI Pyramidal Neuron	spike width (ms)	2002.0 ± 147.0	--	Data Table