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Article: Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Lau D; Vega-Saenz de Miera EC; Contreras D; Ozaita A; Harvey M; Chow A; Noebels JL; Paylor R; Morgan JI; Leonard CS; Rudy B
J. Neurosci., 2000

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron adaptation ratio 0.85 ± 0.018 (20) 0.85 (ratio) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron adaptation ratio 0.8 ± 0.023 (10) 0.8 (ratio) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron fast AHP amplitude (mV) 16.14 ± 0.68 (20) 16.14 (mV) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron fast AHP amplitude (mV) 17.64 ± 1.06 (10) 17.64 (mV) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron firing frequency (Hz) 152.11 ± 7.04 (20) 152.11 (Hz) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron firing frequency (Hz) 134.47 ± 7.52 (10) 134.47 (Hz) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron input resistance (MΩ) 133.37 ± 6.19 (20) 133.37 (MΩ) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron input resistance (MΩ) 153.5 ± 17.92 (10) 153.5 (MΩ) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron resting membrane potential (mV) -64.45 ± 0.54 (20) -64.45 (mV) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron resting membrane potential (mV) -64.22 ± 0.75 (10) -64.22 (mV) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron spike half-width (msec) 0.74 ± 0.018 (20) 0.74 (ms) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron spike half-width (msec) 0.78 ± 0.031 (10) 0.78 (ms) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron spike max decay slope (mV/msec) -84.07 ± 1.84 (20) 84.07 (mV/ms) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron spike max decay slope (mV/msec) -79.37 ± 5.75 (10) 79.37 (mV/ms) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron spike max rise slope (mV/msec) 155.54 ± 2.9 (20) 155.54 (mV/ms) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron spike max rise slope (mV/msec) 151.65 ± 6.33 (10) 151.65 (mV/ms) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron spike threshold (mV) -38.35 ± 0.59 (20) -38.35 (mV) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron spike threshold (mV) -37.04 ± 1.13 (10) -37.04 (mV) Data Table

Report miscurated data

Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
RecTemp 24.0
Strain C57BL
PrepType in vivo
AnimalAge 15.0 - 21.0
InternalSolution 5.0
ExternalSolution 5.0
JxnPotential Unreported
internal_0_Mg 7.0
internal_0_K 144.0
internal_0_GTP 0.5
internal_0_ATP 4.0
internal_0_EGTA 0.2
internal_0_HEPES 10.0
internal_0_Cl 6.0
external_0_pH 7.4
external_0_Mg 2.0
external_0_Na 151.25
external_0_K 5.0
external_0_Cl 133.0
external_0_Ca 2.0
external_0_glucose 10.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
3096 Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. Lau D; Vega-Saenz de Miera EC; Contreras D; Ozaita A; Harvey M; Chow A; Noebels JL; Paylor R; Morgan JI; Leonard CS; Rudy B J. Neurosci. 2000 False 9 Shreejoy Tripathy, Kerrie Tsigounis, Brenna Li, Patrick Savage, 3