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Article: A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Otto JF; Yang Y; Frankel WN; White HS; Wilcox KS
J. Neurosci., 2006

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell access resistance (MΩ) 13.2 ± 0.5 (25) 13.2 (MΩ) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 111.0 ± 4.0 (25) 111.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell membrane time constant 157.0 ± 13.0 (25) 157.0 (ms) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -60.1 ± 0.4 (25) -60.1 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.52 ± 0.04 (25) 1.52 (ms) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -46.2 ± 0.7 (25) -46.2 (mV) Data Table

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Metadata values

Experimental condition Value
AnimalAge 56.0 - 84.0
Strain C57BL
PrepType in vitro
ElectrodeType Patch-clamp
Species Mice
InternalSolution 5.0
ExternalSolution 5.0
JxnPotential Unreported
AnimalWeight 15.0 - 25.0
RecTemp 21.0 - 23.0
internal_0_pH 7.28
internal_0_Mg 0.2
internal_0_K 150.0
internal_0_HEPES 10.0
internal_0_Cl 10.4
external_0_Mg 2.0
external_0_Na 153.4
external_0_K 3.0
external_0_Cl 134.4
external_0_Ca 2.0
external_0_glucose 10.0
external_0_picro 50.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
2379 A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons. Otto JF; Yang Y; Frankel WN; White HS; Wilcox KS J. Neurosci. 2006 False 6 Shreejoy Tripathy, Patrick Savage, Ellie Hogan, 2
2380 A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons. Otto JF; Yang Y; Frankel WN; White HS; Wilcox KS J. Neurosci. 2006 False 0 None