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Article: Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Hall AM; Throesch BT; Buckingham SC; Markwardt SJ; Peng Y; Wang Q; Hoffman DA; Roberson ED J. Neurosci., 2015
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Hippocampus CA1 pyramidal cell | AHP amplitude (mV) | 6.85 ± 0.47 (31) | 6.85 (mV) | Data Table | |
| Hippocampus CA1 pyramidal cell | spike amplitude (mV) | 96.78 ± 1.0 (31) | 96.78 (mV) | Data Table | |
| Hippocampus CA1 pyramidal cell | spike half-width (ms) | 0.76 ± 0.12 (31) | 0.76 (ms) | Data Table | |
| Hippocampus CA1 pyramidal cell | spike threshold (mV) | -46.1 ± 0.65 (31) | -46.1 (mV) | Data Table |
Metadata values
| Experimental condition | Value |
|---|---|
| Species | Mice |
| ElectrodeType | Patch-clamp |
| Strain | Mice, Transgenic |
| PrepType | in vitro |
| ExternalSolution | 5.0 |
| InternalSolution | 5.0 |
| external_1_Mg | 2.5 |
| external_1_Ca | 0.5 |
| external_1_Na | 31.8 |
| external_1_Cl | 118.5 |
| external_1_K | 2.5 |
| internal_1_pH | 7.3 |
| internal_1_Mg | 2.0 |
| internal_1_Na | 4.0 |
| internal_1_Cl | 24.0 |
| internal_1_K | 149.0 |
| JxnPotential | Unreported |
| RecTemp | 31.0 |
| internal_0_pH | 7.2 |
| internal_0_Mg | 4.0 |
| internal_0_Na | 24.0 |
| internal_0_K | 145.0 |
| internal_0_GTP | 0.3 |
| internal_0_ATP | 4.0 |
| internal_0_EGTA | 0.5 |
| internal_0_HEPES | 10.0 |
| internal_0_Cl | 24.0 |
| external_0_pH | 7.3 |
| external_0_Mg | 1.0 |
| external_0_Na | 154.25 |
| external_0_K | 2.5 |
| external_0_Cl | 133.5 |
| external_0_Ca | 2.0 |
| external_0_glucose | 25.0 |
| external_0_DNQX | 10.0 |
| external_0_BIC | 20.0 |
| external_0_DAPV | 250.0 |
Data table listing
| Data Table | Article Title | Authors | Journal | Year | Table needs expert? | Ephys table mentions | Curated by | Times validated |
|---|---|---|---|---|---|---|---|---|
| 46519 | Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease. | Hall AM; Throesch BT; Buckingham SC; Markwardt SJ; Peng Y; Wang Q; Hoffman DA; Roberson ED | J. Neurosci. | 2015 | False | 4 | Brenna Li, Ryan Sefidpour, | 2 |