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Article: Permanent reduction of seizure threshold in post-ischemic CA3 pyramidal neurons.

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Congar P; Gaïarsa JL; Popovici T; Ben-Ari Y; Crépel V
J. Neurophysiol., 2000


Table 1.

Long-term effect of global ischemic insult on intrinsic properties of resistant CA3 pyramidal neurons

Parameters Control Cells Post-Ischemic Cells
V rest(mV) −72.6 ± 1.8 (17) −67.6 ± 1.4 (16)*
Input resistance (MΩ) 79.8 ± 7.3 (17) 84.3 ± 9.5 (16)
Spike threshold (mV) −55.5 ± 1.0 (17) −56.65 ± 0.95 (16)
Spike amplitude (mV) 74.5 ± 1.6 (17) 77.9 ± 1.9 (16)
fAHP amplitude (mV) 4.5 ± 0.3 (15) 5.2 ± 0.5 (15)
ADP amplitude (mV) 3.1 ± 0.3 (8) 3.05 ± 0.7 (5)
Burst duration (ms) 50.7 ± 6 (9) 58.8 ± 7.3 (10)
Spike frequency (Hz) 118 ± 9.3 (9) 130.6 ± 9.9 (10)
V rest–spike threshold (mV) 15.85 ± 1.9 (17) 10.7 ± 1.8 (16)*
  • Values are means ± SE with number of cells in parentheses. * P < 0.05, Student's t-test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA3 pyramidal cell spike amplitude (mV) 74.5 ± 1.6 74.5 (mV) Data Table
Hippocampus CA3 pyramidal cell fast AHP amplitude (mV) 4.5 ± 0.3 4.5 (mV) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -72.6 ± 1.8 -72.6 (mV) Data Table
Hippocampus CA3 pyramidal cell firing frequency (Hz) 118.0 ± 9.3 118.0 (Hz) Data Table
Hippocampus CA3 pyramidal cell input resistance (MΩ) 79.8 ± 7.3 79.8 (MΩ) Data Table
Hippocampus CA3 pyramidal cell spike threshold (mV) -55.5 ± 1.0 -55.5 (mV) Data Table