N | RMP, mV | RIN, MΩ | τc, ms | AP Amp, mV | AP Dur, | AHP Amp, | AHP Time to Peak, ms | SFA τc, ms | |
---|---|---|---|---|---|---|---|---|---|
ms | mV | ||||||||
P10 neurons | |||||||||
Control | 4 | −58 ± 5.1 | 63.5 ± 20.8 | 32.6 ± 2.6 | 55.4 ± 4.4 | 3.1 ± 0.3 | n.a. | n.a. | 26.4 ± 8.2 |
Cocaine | 4 | −64.2 ± 6.2 | 146.7 ± 41.3 | 39.2 ± 4.5 | 52.4 ± 4.3 | 2.9 ± 0.4 | n.a. | n.a. | 92.1 ± 41.3 |
P15 neurons | * | ||||||||
Control | 8 | −58.3 ± 4.3 | 62.1 ± 9 | 35.3 ± 0.9 | 58.7 ± 2.2 | 1.9 ± 0.1 | 10.4 ± 3.7 | 150.6 ± 26.3 | 26 ± 9.3 |
Cocaine | 6 | −60.6 ± 4 | 70.2 ± 18.5 | 37.5 ± 1 | 54.7 ± 6.7 | 1.4 ± 0.4 | 3.3 ± 1.1 | 65 ± 30.9 | 73.1 ± 23.4 |
P20 neurons | * | * | |||||||
Control | 11 | −66.9 ± 3.7 | 115 ± 9.7 | 36.7 ± 0.6 | 62.1 ± 2.8 | 1.9 ± 0.1 | 11.3 ± 3 | 222.3 ± 22.9 | 15.9 ± 1.3 |
Cocaine | 10 | −73.7 ± 11.7 | 88.8 ± 9.7 | 36.3 ± 0.8 | 61 ± 2.9 | 2.1 ± 0.2 | 10.2 ± 1.6 | 136.2 ± 27.7 | 93.5 ± 21.1 |
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Values are means ± SE. n.a., not applicable; for other abbreviations, see Table 1. DAP and sag were not consistently observed in granule cells atany age tested. In 3 granule cells the SFA time constant plot was fit using 2 exponentials; SFA time constants for these cells were 9.8 ± 2 ms and194.5 ± 8.7 ms, respectively (see Fig. 2 C3). For group comparisons a single time constant was obtained from the average of these 2 SFA time constants.* P < 0.05.