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Article: Glutamatergic nonpyramidal neurons from neocortical layer VI and their comparison with pyramidal and spiny stellate neurons.

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Andjelic S; Gallopin T; Cauli B; Hill EL; Roux L; Badr S; Hu E; Tamás G; Lambolez B
J. Neurophysiol., 2009


TABLE 2.

Electrophysiological properties of neocortical glutamatergic neurons

Property Nonpyramidal VGluT1+ Layer VI (L6, n = 71) Spiny Stellate Layer IV (St, n = 10) Pyramidal Layer V (L5, n = 33) Pyramidal Layers II/III (L2/3, n = 28)
Input resistance, MΩ 385.30 ± 122.3 451.2 ± 158.4 159.7 ± 72.5 316.6 ± 77.6
St –L6 > L2/3 ≫ L5
Sag, membrane resistance decrease, % 10.10 ± 6.3 16.6 ± 7.0 25.7 ± 5.5 16.4 ± 6.3
L5 ≫ St –L2/3; L5 ≫ L6; St > L6
First spike amplitude, mV 91.20 ± 8.6 85.9 ± 17.1 96.5 ± 4.9 84.7 ± 8.2
L5 ≫ L6 –St; L6 ≫ L2/3; St –L2/3
Second spike amplitude, mV 87.60 ± 10.3 77.2 ± 17.3 93.9 ± 5.1 81.8 ± 9.1
L5 ≫ L6 ≫ L2/3 –St
Amplitude reduction, % 4.07 ± 4.3 9.8 ± 5.6 2.6 ± 1.9 3.5 ± 4.2
St ≫ L6 –L2/3 –L5
First spike duration, ms 1.90 ± 0.3 1.4 ± 0.4 1.4 ± 0.2 1.3 ± 0.3
L6 ≫ L2/3 –L5 –St
Second spike duration, ms 2.20 ± 0.5 1.9 ± 0.6 1.7 ± 0.4 1.6 ± 0.4
L6 ≫ L2/3 –L5; L6 –St; St > L2/3 –L5
Duration increase, % 15.30 ± 11.5 36.4 ± 15.5 13.8 ± 10.6 23.4 ± 13.8
St > L2/3 ≫ L6 –L5
First AHP, mV −13.20 ± 4.1 −6.2 ± 5.9 −9.0 ± 3.5 −9.6 ± 2.9
L6 ≫ L2/3 –L5 > St
Second AHP, mV −15.20 ± 3.3 −11.7 ± 4.8 −13.0 ± 2.0 −13.4 ± 2.0
L6 ≫ L2/3 –L5 –St
Early adaptation, % 48.70 ± 12.6 65.8 ± 18.3 59.5 ± 9.4 57.6 ± 10.0
L2/3 –L5 ≫ L6; L2/3 –L5 –St; St > L6
Late adaptation, % 17.50 ± 9.4 24.4 ± 9.9 11.5 ± 8.3 20.1 ± 10.3
St –L2/3 –L6 ≫ L5

  • Values are means ± SD; n is the number of cells; > significantly greater with P ≤ 0.005; ≫ significantly greater with P ≤ 0.001; –not significantly different. Statistically significant differences were determined using the Mann–Whitney U test. Electrophysiological parameters were measured as described in methods.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Layer 6 sensorimotor cortex nonpyramidal VGluT1 expressing neurons input resistance (MΩ) 385.3 ± 122.3 (71) 385.3 (MΩ) Data Table
Neocortex layer 4 stellate cell Layer 4 sensorimotor cortex spiny stellate neurons input resistance (MΩ) 451.2 ± 158.4 (10) 451.2 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 sensorimotor cortex pyramidal neurons input resistance (MΩ) 159.7 ± 72.5 (33) 159.7 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 sensorimotor cortex pyramidal neurons input resistance (MΩ) 316.6 ± 77.6 (28) 316.6 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6 sensorimotor cortex nonpyramidal VGluT1 expressing neurons sag ratio 10.1 ± 6.3 (71) 0.101 (ratio) Data Table
Neocortex layer 4 stellate cell Layer 4 sensorimotor cortex spiny stellate neurons sag ratio 16.6 ± 7.0 (10) 0.166 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 sensorimotor cortex pyramidal neurons sag ratio 25.7 ± 5.5 (33) 0.257 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 sensorimotor cortex pyramidal neurons sag ratio 16.4 ± 6.3 (28) 0.164 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6 sensorimotor cortex nonpyramidal VGluT1 expressing neurons spike amplitude (mV) 91.2 ± 8.6 (71) 91.2 (mV) Data Table
Neocortex layer 4 stellate cell Layer 4 sensorimotor cortex spiny stellate neurons spike amplitude (mV) 85.9 ± 17.1 (10) 85.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 sensorimotor cortex pyramidal neurons spike amplitude (mV) 96.5 ± 4.9 (33) 96.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 sensorimotor cortex pyramidal neurons spike amplitude (mV) 84.7 ± 8.2 (28) 84.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6 sensorimotor cortex nonpyramidal VGluT1 expressing neurons spike half-width (ms) 1.9 ± 0.3 (71) 1.9 (ms) Data Table
Neocortex layer 4 stellate cell Layer 4 sensorimotor cortex spiny stellate neurons spike half-width (ms) 1.4 ± 0.4 (10) 1.4 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 sensorimotor cortex pyramidal neurons spike half-width (ms) 1.4 ± 0.2 (33) 1.4 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 sensorimotor cortex pyramidal neurons spike half-width (ms) 1.3 ± 0.3 (28) 1.3 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6 sensorimotor cortex nonpyramidal VGluT1 expressing neurons AHP amplitude (mV) -13.2 ± 4.1 (71) 13.2 (mV) Data Table
Neocortex layer 4 stellate cell Layer 4 sensorimotor cortex spiny stellate neurons AHP amplitude (mV) -6.2 ± 5.9 (10) 6.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 sensorimotor cortex pyramidal neurons AHP amplitude (mV) -9.0 ± 3.5 (33) 9.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 sensorimotor cortex pyramidal neurons AHP amplitude (mV) -9.6 ± 2.9 (28) 9.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Layer 6 sensorimotor cortex nonpyramidal VGluT1 expressing neurons adaptation percent (1 – first/last ISI) 48.7 ± 12.6 (71) 48.7 (ratio) Data Table
Neocortex layer 4 stellate cell Layer 4 sensorimotor cortex spiny stellate neurons adaptation percent (1 – first/last ISI) 65.8 ± 18.3 (10) 65.8 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Layer 5 sensorimotor cortex pyramidal neurons adaptation percent (1 – first/last ISI) 59.5 ± 9.4 (33) 59.5 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 sensorimotor cortex pyramidal neurons adaptation percent (1 – first/last ISI) 57.6 ± 10.0 (28) 57.6 (ratio) Data Table