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Article: Myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice.

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Sutor B; Schmolke C; Teubner B; Schirmer C; Willecke K
Cereb. Cortex, 2000


Table 2

Comparison of electrophysiological parameters determined in neocortical neurons of wild-type and Cx32-deficient mice

Wild-type mice Cx32-deficient mice Difference (in %)
Values given as mean ± SD; *significantly different at the 5% level; NS, not significant.
aFor calculation see text.
bNecessary to evoke a single action potential.
Resting membrane potential (in mV, n = 24/30) -85.21 ± 6.12 -84.37 ± 5.90 1.0 (NS)
Input resistance (in MΩ, n = 24/30)  46.74 ± 14.98 59.57 ± 19.86 27.4* (P = 0.011)
Membrane time constant τ0 (in ms, n = 24/29)  9.36 ± 2.02 10.44 ± 3.39 11.5 (NS)
First equalizing time constant τ1 (in ms, n = 24/29)  1.67 ± 0.70 1.34 ± 1.50 19.8* (P = 0.047)
Slope of IV curve at -0.2 nA (in MΩ, n = 9/11)  39.61 ± 13.85 55.19 ± 10.54 28.2* ( P = 0.010)
Slope of IV curve at +0.2 nA (in MΩ, n = 9/11)  68.63 ± 30.19 100.10 ± 21.81 31.4* (P = 0.015)
Rectification ratioa (n = 9/11)  1.72 ± 0.33 1.84 ± 0.26 6.5 (NS)
Threshold currentb (in nA, n = 17/21)  0.53 ± 0.16 0.39 ± 0.15 26.4* (P = 0.006)
Slope of steady-state f-I plot (in Hz/nA, n = 11/11)  71.1 ± 16.4 93.3 ± 23.6 24.2* (P = 0.019)

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 neocortical layer 2-3 regular spiking pyramidal cells resting membrane potential -85.21 ± 6.12 (24) -85.21 (mV) Data Table
Neocortex pyramidal cell layer 2-3 neocortical layer 2-3 regular spiking pyramidal cells input resistance 46.74 ± 14.98 (24) 46.74 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 neocortical layer 2-3 regular spiking pyramidal cells membrane time constant 9.36 ± 2.02 (24) 9.36 (ms) Data Table
Neocortex pyramidal cell layer 2-3 neocortical layer 2-3 regular spiking pyramidal cells membrane time constant 1.67 ± 0.7 (24) 1.67 (ms) Data Table
Neocortex pyramidal cell layer 2-3 neocortical layer 2-3 regular spiking pyramidal cells rheobase 0.53 ± 0.16 (24) -- Data Table
Neocortex pyramidal cell layer 2-3 neocortical layer 2-3 regular spiking pyramidal cells FI slope 71.1 ± 16.4 (24) 71.1 (Hz/nA) Data Table