TABLE 3.Action potential properties of CA1 pyramidal cells recorded from control and choline supplemented rats
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Parameters |
Control |
n |
Supplementation |
n |
P value |
Spike threshold (mV) | -43.5 ± 0.74 | 32 | 44.6 ± 0.75 | 32 | 0.145 |
Rheobase (pA) | 76.2 ± 4.9 | 32 | 66.6 ± 4.2 | 32 | 0.069 |
Spike amplitude (mV) | |||||
x=ns\x=ns First spike | 97.1 ± 1.8 | 32 | 94.2 ± 2.0 | 32 | 0.151 |
x=ns\x=ns Second spike | 93.6 ± 1.5 | 32 | 89.7 ± 1.8 | 32 | 0.061 |
x=ns\x=ns Third spike | 93.4 ± 1.2 | 32 | 90.1 ± 1.8 | 32 | 0.063 |
Spike duration (ms) | |||||
x=ns\x=ns First spike | 3.22 ± 0.15 | 32 | 3.12 ± 0.09 | 32 | 0.288 |
x=ns\x=ns Second spike | 3.39 ± 0.12 | 32 | 3.29 ± 0.12 | 32 | 0.269 |
x=ns\x=ns Third spike | 3.57 ± 0.09 | 32 | 3.50 ± 0.10 | 32 | 0.306 |
Spike duration at half amplitude (ms) | |||||
x=ns\x=ns First spike | 1.25 ± 0.06 | 32 | 1.22 ± 0.06 | 32 | 0.364 |
x=ns\x=ns Second spike | 1.58 ± 0.09 | 32 | 1.52 ± 0.08 | 32 | 0.303 |
x=ns\x=ns Third spike | 1.57 ± 0.08 | 32 | 1.50 ± 0.08 | 32 | 0.239 |
ADP (mV) | 1.19 ± 0.08 | 24 | 3.84 ± 0.34 | 24 | 0.0008 |
ADP duration (ms) |
4.37 ± 0.78 |
24 |
7.12 ± 0.82 |
24 |
0.008 |
Values are mean ± SE. ADP, afterdepolarizing potential.