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Article: Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins.

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Lau D; Vega-Saenz de Miera EC; Contreras D; Ozaita A; Harvey M; Chow A; Noebels JL; Paylor R; Morgan JI; Leonard CS; Rudy B
J. Neurosci., 2000


Table 1.

Comparison of firing properties between wild-type and mutant FS cells in the neocortex

Layer V–VI Layer I–IV
p Wild-type n = 20 Knock-out n = 20 p Wild-type n = 10 Knock-out n = 10
Resting V m(mV) --- −64.45  ± 0.54 −63.60  ± 0.57 --- −64.22  ± 0.75 −64.10  ± 0.60
R input(MΩ) --- 133.37  ± 6.19 142.42 ± 8.61 --- 153.50  ± 17.92 116.10  ± 8.60
Threshold (mV) --- −38.35  ± 0.59 −38.81  ± 1.02 --- −37.04  ± 1.13 −38.27  ± 0.67
Maximum rising slope (mV/msec) --- 155.54  ± 2.90 149.65  ± 8.04 --- 151.65  ± 6.33 165.36  ± 7.53
Maximum falling slope (mV/msec) *** −84.07  ± 1.84 −61.11  ± 5.07 --- −79.37  ± 5.75 −86.08  ± 4.75
Spike width at half amplitude (msec) *** 0.74  ± 0.018 0.94  ± 0.038 --- 0.78  ± 0.031 0.75  ± 0.036
AHP Amp (mV) ** 16.14  ± 0.68 12.34  ± 0.79 --- 17.64  ± 1.06 15.86  ± 0.69
AHP deceleration (mV/msec2) *** 133.88  ± 5.71 84.11  ± 7.34 --- 130.00  ± 8.63 135.96  ± 12.49
SS firing rate (Hz) * 152.11  ± 7.04 116.63  ± 10.21 --- 134.47  ± 7.52 155.21  ± 13.35
SS firing rate/initial frequency ** 0.85  ± 0.018 0.71  ± 0.031 --- 0.80  ± 0.023 0.83  ± 0.035
  • FS cells are organized by the cortical layer in which they were found. Spike width, AHP, and slope measurements are from single action potentials. V m, Membrane potential;R input, input resistance of the cell; Amp, amplitude; SS, steady state. p values determined by Student's t test. *p < 0.01; **p < 0.001; ***p < 0.0001; dashed lines indicate non- significance (p > 0.05).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron input resistance (MΩ) 133.37 ± 6.19 (20) 133.37 (MΩ) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron input resistance (MΩ) 153.5 ± 17.92 (10) 153.5 (MΩ) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron spike threshold (mV) -38.35 ± 0.59 (20) -38.35 (mV) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron spike threshold (mV) -37.04 ± 1.13 (10) -37.04 (mV) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron spike max rise slope (mV/msec) 155.54 ± 2.9 (20) 155.54 (mV/ms) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron spike max rise slope (mV/msec) 151.65 ± 6.33 (10) 151.65 (mV/ms) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron resting membrane potential (mV) -64.45 ± 0.54 (20) -64.45 (mV) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron spike max decay slope (mV/msec) -84.07 ± 1.84 (20) 84.07 (mV/ms) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron spike max decay slope (mV/msec) -79.37 ± 5.75 (10) 79.37 (mV/ms) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron spike half-width (msec) 0.74 ± 0.018 (20) 0.74 (ms) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron spike half-width (msec) 0.78 ± 0.031 (10) 0.78 (ms) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron fast AHP amplitude (mV) 16.14 ± 0.68 (20) 16.14 (mV) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron fast AHP amplitude (mV) 17.64 ± 1.06 (10) 17.64 (mV) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron firing frequency (Hz) 152.11 ± 7.04 (20) 152.11 (Hz) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron resting membrane potential (mV) -64.22 ± 0.75 (10) -64.22 (mV) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron firing frequency (Hz) 134.47 ± 7.52 (10) 134.47 (Hz) Data Table
Neocortex basket cell Neocortex layer 5-6 fast-spiking GABAergic interneuron adaptation ratio 0.85 ± 0.018 (20) 0.85 (ratio) Data Table
Neocortex basket cell Neocortex layer 1-4 fast-spiking GABAergic interneuron adaptation ratio 0.8 ± 0.023 (10) 0.8 (ratio) Data Table