AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Activation of presynaptic cAMP-dependent protein kinase is required for induction of cerebellar long-term potentiation.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Linden DJ; Ahn S
J. Neurosci., 1999


Table 1.

Effects of PKA manipulations on some basal properties of granule cell–Purkinje neuron synapses in culture

Measure Control KT5720 bath Rp-8CPT-cAMP-S bath RSV-PKI granule RSV-PKImut granule
R input(MΩ) 181  ± 28  174  ± 22 173  ± 30 190  ± 25 187  ± 21
mEPSC frequency (sec−1) 7.9  ± 2.6 6.2  ± 2.0 6.1  ± 2.3 7.8  ± 2.9 7.0  ± 3.0
mEPSC amplitude (pA) 27  ± 7 31  ± 8 30  ± 6 24  ± 7 22  ± 5
Failures (%) 35  ± 6 42  ± 5 41  ± 7 33  ± 7 34  ± 9
Evoked EPSC amplitude (pA) 102  ± 30 90  ± 26 92  ± 30 88  ± 33 106  ± 26
Paired-pulse facilitation (%) 164  ± 10 189  ± 15 183  ± 16 181  ± 13 161  ± 12
  • Values are mean ± SEM. n = 10 cell pairs per group. For each cell pair, measurements were made as follows.R input was determined by measuring the sustained current deflection during a voltage step from −80 to −90 mV imposed on the Purkinje neuron. mEPSC frequency and amplitude measurements were made using the same 500-sec-long sample recorded in 0.5 μm tetrodotoxin. Failure rate was calculated from a sample of 100 pulses applied at 0.05 Hz. Mean evoked EPSC amplitudes were measured by averaging responses to 50 consecutive paired stimuli (50 msec interpulse interval) applied at 0.05 Hz and were then normalized to derive the percentage facilitation measure.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum Purkinje cell input resistance (MΩ) 181.0 ± 28.0 (10) 181.0 (MΩ) Data Table