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Article: Developmental synaptic changes increase the range of integrative capabilities of an identified excitatory neocortical connection.

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Angulo MC; Staiger JF; Rossier J; Audinat E
J. Neurosci., 1999


Table 1.

Action potential firing and unitary EPSC properties of postsynaptic FS interneurons at two different developmental stages

Connections from 3-week-old rats mean ± SD (n) Connections from 5-week-old rats mean ± SD (n)
Postnatal days 17  ± 1 (36) 33  ± 2 (21)
Firing Properties1-a
 Early accommodation 15  ± 15% (36) 12  ± 13% (20)
 Late accommodation 3  ± 10% (36) 4  ± 9% (20)
 Spike amplitude (A) 78  ± 8 mV (36) 81  ± 5 mV (20)
 Spike duration (t 1/2) 0.4  ± 0.1 msec (36) 0.31  ± 0.06 msec (20)
 AHP −21  ± 3 mV (36) −25  ± 3.3 mV (20)
 Rin 0.16  ± 0.06 GΩ (36) 0.14  ± 0.04 GΩ (20)
 Vrmp −73  ± 8 mV (34) −76  ± 3.1 mV (20)
Unitary EPSCs
 Latency 0.47  ± 0.28 msec (36) 0.54  ± 0.26 msec (21)
 1st exponential decay (τ1) 1.3  ± 0.5 msec (22) 1.3  ± 0.6 msec (15)
 Amplitude of τ1 88  ± 12% (22) 89  ± 7% (15)
 2nd exponential decay (τ2) 11  ± 6 msec (22) 17  ± 15 msec (15)
 Amplitude of τ2 12  ± 12% (22) 11  ± 7% (15)
 τ1-b 1.7  ± 0.5 msec (13) 1.7  ± 0.4 msec (4)
 NBQX/DNQX Block (−72 mV) 98  ± 2% (5) 96.5% and 99.2% (2)
  • F1-a  There were no statistical differences of action potential and firing kinetics between 3- and 5-week-old rats, except for t 1/2 and AHP (p < 0.05; Student’s t test).

  • F1-b  mean τ of EPSCs well fitted with a single exponential function.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons spike amplitude (A) 78.0 ± 8.0 (36) -- Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons spike amplitude (A) 81.0 ± 5.0 (20) -- Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons spike half-width 0.4 ± 0.1 (36) 0.4 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons spike half-width 0.31 ± 0.06 (20) 0.31 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons AHP amplitude -21.0 ± 3.0 (36) 21.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons AHP amplitude -25.0 ± 3.3 (20) 25.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons input resistance 0.16 ± 0.06 (36) 160.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons input resistance 0.14 ± 0.04 (20) 140.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons resting membrane potential -73.0 ± 8.0 (34) -73.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons resting membrane potential -76.0 ± 3.1 (20) -76.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons adaptation percent (1 – first/last ISI) 15.0 ± 15.0 (36) 15.0 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Motor cortex layer 5 glutamatergic excitatory pyramidal neurons synapsing onto motor cortex layer 5 fast-spiking interneurons adaptation percent (1 – first/last ISI) 12.0 ± 13.0 (20) 12.0 (ratio) Data Table