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Article: Dopamine modulates the responsivity of mediodorsal thalamic cells recorded in vitro.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Lavin A; Grace AA J. Neurosci., 1998
Table 2.
Effects of D2 agonist quinpirole and D2 antagonist haloperidol on basic membrane properties of thalamic cells
| Hyperpolarize (n = 19) | Depolarize (n = 7) | No changes (n = 11) | ||||
|---|---|---|---|---|---|---|
| Control | Quinpirole | Control | Quinpirole | Control | Quinpirole | |
| Membrane potential (mV) | 65.5 ± 4.7 | 71.7 ± 6.7* | 67.8 ± 10.9 | 64.4 ± 12.0** | 63.0 ± 5.4 | 63.7 ± 5.3 |
| Changes in membrane potential (mV) | 5.9 ± 4.9 | 3.4 ± 0.7 | 0.7 ± 2.7 | |||
| Input resistance (MΩ) | 33.8 ± 13.4 | 41.3 ± 19.1 | 32.4 ± 21.0 | 47.2 ± 18.4 | 39.3 ± 18.1 | 37.3 ± 20.5 |
| Spike threshold (mV) | 48.5 ± 4.3 | 51.1 ± 11.8 | 52.4 ± 7.2 | 45.5 ± 8.6*** | 49.0 ± 7.2 | 41.9 ± 6.3 |
| Current threshold (nA) | 0.44 ± 0.26 | 0.27 ± 0.17 | 0.31 ± 0.11 | 0.08 ± 0.05**** | 0.44 ± 0.30 | 0.25 ± 0.35 |
| LTS-evoked (rebound) | 2/19 | 10/19+ | 4/7 | 1/7 | 2/11 | 4/11 |
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*p < 0.0031; t = −5.50.
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**p < 0.0006; t = 2.57.
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***p < 0.04; t = 3.27.
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****p < 0.005; t = 5.38.
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+ p < 0.0005 (plotting together all controls vs all LTSs).
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Thalamus relay cell | resting membrane potential (mV) | 65.5 ± 4.7 | -65.5 (mV) | Data Table | |
| Thalamus relay cell | input resistance (MΩ) | 33.8 ± 13.4 | 33.8 (MΩ) | Data Table | |
| Thalamus relay cell | spike threshold (mV) | 48.5 ± 4.3 | -48.5 (mV) | Data Table | |
| Thalamus relay cell | rheobase (nA) | 0.44 ± 0.26 | 440.0 (pA) | Data Table |