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Article: Activity-dependent modulation of layer 1 inhibitory neocortical circuits by acetylcholine.

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Brombas A; Fletcher LN; Williams SR
J. Neurosci., 2014


Table 1.

Electrophysiological and morphological properties of NGFCs and c-ACs

NGFCs (n) c-ACs (n)
Resting membrane potential -77.0 ± 0.5 mV (72) -75.9 ± 0.73 mV (31)
Apparent input resistance 109.3 ± 3.8 MΩ (72) 123.2 ± 6.0 MΩ (31)
Action potential accommodation index 0.42 ± 0.06 (72) -0.42 ± 0.07 (34)
Action potential after-hyperpolarization -24.9 ± 0.4 mV (68) -15.2 ± 0.9 mV (28)
Dendritic field area 0.013 ± 0.006 mm2 (5) 0.041 ± 0.007 mm2 (7)
Axonal density 0.191 ± 0.036 μm-1 (5) 0.064 ± 0.014 μm-1 (7)

  • Analysis revealed that interneuronal classes could be divided electrophysiologically by statistically significant differences in apparent input resistance (measured in response to a -20 pA current step; Students t test: T = 1.99, p = 0.0483), action potential accommodation index (calculated as the ratio of the first and last interspike interval, in response to positive current steps of magnitude set to the rheobase for the generation of repetitive action potential firing; Mann-Whitney test: U = 73.5, p < 0.0001), and the amplitude of the action potential after-hyperpolarization (measured from single action potential generated at rheobase; Students t test: T = 12.28, p < 0.0001). Morphological analysis revealed that the dendritic field area (Students t test: T = 2.76, p = 0.02) and axonal density (total axonal length/axonal field area; Students t test: T = 3.70, p = 0.0041) of interneuronal classes were significantly different. Values represent mean ± SEM.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Somatosensory cortex layer 1 cholinergic excitatory neurogliaform cells AHP duration -24.9 ± 0.4 (68) -- Data Table
Other Somatosensory cortex layer 1 cholinergic excitatory classical-accommodating cells AHP duration -15.2 ± 0.9 (28) -- Data Table
Other Somatosensory cortex layer 1 cholinergic excitatory neurogliaform cells resting membrane potential -77.0 ± 0.5 (72) -77.0 (mV) Data Table
Other Somatosensory cortex layer 1 cholinergic excitatory classical-accommodating cells resting membrane potential -75.9 ± 0.73 (31) -75.9 (mV) Data Table
Other Somatosensory cortex layer 1 cholinergic excitatory neurogliaform cells input resistance 109.3 ± 3.8 (72) 109.3 (MΩ) Data Table
Other Somatosensory cortex layer 1 cholinergic excitatory classical-accommodating cells input resistance 123.2 ± 6.0 (31) 123.2 (MΩ) Data Table