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Article: Homeostatic dysregulation in membrane properties of masticatory motoneurons compared with oculomotor neurons in a mouse model for amyotrophic lateral sclerosis.

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Venugopal S; Hsiao CF; Sonoda T; Wiedau-Pazos M; Chandler SH
J. Neurosci., 2015


Table 1.

Membrane properties of WT and SOD1G93A TMNs classified by predicted MU type

Membrane property PS PFR PFF
WT (n = 16) SOD1G93A (n = 12) WT (n = 16) SOD1G93A (n = 9) WT (n = 16) SOD1G93A (n = 15)
Cm, pF 115.0 ± 8.4 114.0 ± 7.8 142.2 ± 11.0 111.7 ± 8.3 185.6 ± 21.2 144.7 ± 10.5
Rinp, MΩ 132.8 ± 12.8 131.7 ± 8.4 59.1 ± 3.9 78.6 ± 5.3* 35.7 ± 2.2 51.4 ± 3.0**
RMP, mV -61.6 ± 1.8 -60.1 ± 1.6 -65.5 ± 1.2 -65.9 ± 2.4 -67.4 ± 1.6 -64.4 ± 1.5
Rheobase, pA 151.6 ± 13.8 123.8 ± 13.8 459.1 ± 30.2 274.4 ± 16.5† 800.7 ± 67.3 539.3 ± 19.1††
AP threshold, mV -40.0 ± 1.3 -39.4 ± 1.2 -33.5 ± 1.3 -36.5 ± 2.6 -33.5 ± 2.3 -31.2 ± 1.3
AP height, mV 83.5 ± 2.8 85.7 ± 2.8 79.1 ± 2.2 83.3 ± 3.7 82.1 ± 2.6 73.8 ± 1.5‡
AP half-width, ms 1.0 ± 0.05 0.9 ± 0.1 0.8 ± 0.04 1.0 ± 0.1# 0.7 ± 0.07 0.8 ± 0.0
AHP, mV -5.4 ± 1.3 -3.8 ± 1.1 -4.0 ± 1.1 -5.4 ± 1.5 -3.4 ± 1.1 -3.4 ± 0.7

  • Values reported as mean ± SEM. Student t tests were performed for statistical comparison between WT and SOD1G93A neurons within the three predicted MU types. Symbols indicate statistical significance, where:

  • ↵*p = 0.007,

  • ↵**p = 0.003,

  • ↵†p = 0.00024,

  • ↵††p = 7.83712E-05,

  • ↵‡p = 0.0074,

  • ↵#p = 0.032. Bold face highlights values that show statistical significance in the mutant.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigue resistant motoneurons input resistance (MΩ) 59.1 ± 3.9 (16) 59.1 (MΩ) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigable motoneurons input resistance (MΩ) 35.7 ± 2.2 (16) 35.7 (MΩ) Data Table
Trigeminal nucleus principal cell Trigeminal nucleus predicted slow firing motoneurons resting membrane potential (mV) -61.6 ± 1.8 (16) -61.6 (mV) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigue resistant motoneurons resting membrane potential (mV) -65.5 ± 1.2 (16) -65.5 (mV) Data Table
Trigeminal nucleus principal cell Trigeminal nucleus predicted slow firing motoneurons cell capacitance (pF) 115.0 ± 8.4 (16) 115.0 (pF) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigable motoneurons resting membrane potential (mV) -67.4 ± 1.6 (16) -67.4 (mV) Data Table
Trigeminal nucleus principal cell Trigeminal nucleus predicted slow firing motoneurons rheobase (pA) 151.6 ± 13.8 (16) 151.6 (pA) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigue resistant motoneurons rheobase (pA) 459.1 ± 30.2 (16) 459.1 (pA) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigable motoneurons rheobase (pA) 800.7 ± 67.3 (16) 800.7 (pA) Data Table
Trigeminal nucleus principal cell Trigeminal nucleus predicted slow firing motoneurons spike threshold (mV) -40.0 ± 1.3 (16) -40.0 (mV) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigue resistant motoneurons spike threshold (mV) -33.5 ± 1.3 (16) -33.5 (mV) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigable motoneurons spike threshold (mV) -33.5 ± 2.3 (16) -33.5 (mV) Data Table
Trigeminal nucleus principal cell Trigeminal nucleus predicted slow firing motoneurons spike amplitude (mV) 83.5 ± 2.8 (16) 83.5 (mV) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigue resistant motoneurons spike amplitude (mV) 79.1 ± 2.2 (16) 79.1 (mV) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigue resistant motoneurons cell capacitance (pF) 142.2 ± 11.0 (16) 142.2 (pF) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigable motoneurons spike amplitude (mV) 82.1 ± 2.6 (16) 82.1 (mV) Data Table
Trigeminal nucleus principal cell Trigeminal nucleus predicted slow firing motoneurons spike half-width (ms) 1.0 ± 0.05 (16) 1.0 (ms) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigue resistant motoneurons spike half-width (ms) 0.8 ± 0.04 (16) 0.8 (ms) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigable motoneurons spike half-width (ms) 0.7 ± 0.07 (16) 0.7 (ms) Data Table
Trigeminal nucleus principal cell Trigeminal nucleus predicted slow firing motoneurons AHP amplitude (mV) -5.4 ± 1.3 (16) 5.4 (mV) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigue resistant motoneurons AHP amplitude (mV) -4.0 ± 1.1 (16) 4.0 (mV) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigable motoneurons AHP amplitude (mV) -3.4 ± 1.1 (16) 3.4 (mV) Data Table
Trigeminal nucleus motor neuron Trigeminal nucleus predicted fast fatigable motoneurons cell capacitance (pF) 185.6 ± 21.2 (16) 185.6 (pF) Data Table
Trigeminal nucleus principal cell Trigeminal nucleus predicted slow firing motoneurons input resistance (MΩ) 132.8 ± 12.8 (16) 132.8 (MΩ) Data Table