AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: Characterization of M-current in ventral tegmental area dopamine neurons.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Koyama S; Appel SB
J. Neurophysiol., 2006



TABLE 1.Membrane properties of spontaneously firing DA VTA neurons measured with nystatin-perforated patch recording


Cell capacitance, pF 33.0 ± 0.9 (n = 72)
AP parameters (n = 72)
    Amplitude, mV 74.7 ± 1.1
    Half-width, ms 2.0 ± 0.1
    Threshold, mV –38.6 ± 0.4
    AHP amplitude, mV 26.1 ± 0.6
Input resistance, MΩ 902.4 ± 43.5 (n = 20)
Estimated RMP, mV –48.5 ± 0.7 (n = 20)
Firing frequency, Hz 2.6 ± 0.2 (n = 72)

Values are means ± SE. Numbers of neurons (n) are in parentheses. Cell capacitance was measured after the capacitive transients were cancelled. Action potential (AP) parameters were measured from spontaneous APs recorded in current-clamp mode at resting membrane potential (no current injection). AP amplitude was measured from threshold to AP peak. AP half-width was measured as the duration of the spike halfway between threshold and the AP peak. Afterhyperpolarization (AHP) amplitude was measured from threshold to the peak of the AHP. In 20 of these 72 cells, input resistance and estimated resting membrane potential (RMP) were also measured. Input resistance was determined by hyperpolarizing current pulses that induced a voltage shift of 10–15 mV negative to the resting potential, a voltage range in which Ih (voltage sag on current-clamp recording) was not present (Koyama et al. 2005). Estimated RMP was determined by the membrane potential measured at 60 ms before the peak of the spontaneous AP (Brodie et al. 1999a).

Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Ventral tegmental area dopamine neuron spike half-width (ms) 2.0 ± 0.1 (72) 2.0 (ms) Data Table
Ventral tegmental area dopamine neuron spike threshold (mV) -38.6 ± 0.4 (72) -38.6 (mV) Data Table
Ventral tegmental area dopamine neuron AHP amplitude (mV) 26.1 ± 0.6 (72) 26.1 (mV) Data Table
Ventral tegmental area dopamine neuron input resistance (MΩ) 902.4 ± 43.5 (20) 902.4 (MΩ) Data Table
Ventral tegmental area dopamine neuron resting membrane potential (mV) -48.5 ± 0.7 (20) -48.5 (mV) Data Table
Ventral tegmental area dopamine neuron firing frequency (Hz) 2.6 ± 0.2 (72) 2.6 (Hz) Data Table
Ventral tegmental area dopamine neuron cell capacitance (pF) 33.0 ± 0.9 (72) 33.0 (pF) Data Table
Ventral tegmental area dopamine neuron spike amplitude (mV) 74.7 ± 1.1 (72) 74.7 (mV) Data Table