Parameters | Control mice (wild-type and KCNE1+/−) | KCNE1−/− homozygous mutant mice | ||||
---|---|---|---|---|---|---|
All neurons | Type A | Type B | All neurons | Type A | Type B | |
*Significant differences between the whole sets of neurons recorded on KCNE1−/− versus KCNE1+/− mutant mice. #Significant differences between type A and type B neurons in either KCNE1−/− or KCNE1+/− mice. All numerical values that take part in significant differences are shown in bold. | ||||||
Number and proportion | 21 (100%) | 11 (52%) | 9 (43%) | 16 (100%) | 9 (56%) | 6 (38%) |
Membrane potential (mV) | −53.2 ± 7.7 | −52.6 ± 8.1 | −53.6 ± 8.2 | −48.5 ± 7.8 | −49.5 ± 5.4 | −48.2 ± 10.9 |
Spike threshold (mV) | −42.3 ± 5.8 | −42.6 ± 5.8 | −41.8 ± 6.5 | −39.5 ± 6.9 | −40.8 ± 5.2 | −38.6 ± 9.2 |
Firing rate (spikes s−1) | 25.1 ± 19.7 | 30.2 ± 27.3 | 20.7 ± 8.9 | 21.3 ± 16.8 | 23.4 ± 19.6 | 18.8 ± 15.3 |
Coefficient of variation | 0.16 ± 0.22 | 0.26 ± 0.30 | 0.07 ± 0.07 | 0.29 ± 0.27 | 0.24 ± 0.26 | 0.36 ± 0.31 |
AHPR (V s−1) | 0.57 ± 0.63 | 1.08 ± 0.49 # | 0.03 ± 0.04 # | 0.85 ± 1.20 | 0.97 ± 0.64 # | 0.05 ± 0.05 # |
dAHP (V s−1) | 0.53 ± 0.83 | 0.00 ± 0.00 # | 1.08 ± 0.97 # | 1.32 ± 2.47 | 0.00 ± 0.00 # | 3.48 ± 3.10 # |
Spike width (ms) | 0.79 ± 0.17 | 0.89 ± 0.16 # | 0.70 ± 0.12 # | 0.83 ± 0.25 | 0.90 ± 0.30 | 0.75 ± 0.16 |
Spike height (mV) | 51.8 ± 9.3 | 52.4 ± 6.7 | 50.2 ± 11.9 | 50.4 ± 11.0 | 46.7 ± 5.4 | 57.4 ± 13.8 |
AHP (mV) | 17.8 ± 4.0 | 17.2 ± 3.0 | 18.5 ± 5.2 | 17.1 ± 4.4 | 18.7 ± 4.1 | 15.3 ± 4.7 |
Concavity (mV) | −1.21 ± 1.12 | −2.04 ± 0.86 # | −0.28 ± 0.43 # | −1.71 ± 0.90 | −2.32 ± 1.70 # | −1.07 ± 2.18 # |
Convexity (mV) | 0.76 ± 0.85 * | 0.24 ± 0.35 # | 1.40 ± 0.85 # | 0.21 ± 0.25 * | 0.09 ± 0.07 # | 0.38 ± 0.34 # |
Article: Developmental regulation of the membrane properties of central vestibular neurons by sensory vestibular information in the mouse.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Eugène D; Deforges S; Guimont F; Idoux E; Vidal PP; Moore LE; Vibert N J. Physiol. (Lond.), 2007