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Article: Development of calcium-permeable AMPA receptors and their correlation with NMDA receptors in fast-spiking interneurons of rat prefrontal cortex.

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Wang HX; Gao WJ
J. Physiol. (Lond.), 2010


Table 1. Properties of AMPA and NMDA EPSCs in FS interneurons in the rat prefrontal cortex

CI (RI > 0.7) n = 19 (21.8%) CP (RI < 0.7) n = 68 (78.2%) P value
Age (days)  43.9 ± 7.29  46.4 ± 3.77   0.754 
(PD15–101) (PD15–108)
Rectification index  1.23 ± 0.06  0.21 ± 0.02 <0.0001
(0.76–1.78) (0.01–0.64)
Resting membrane potential (mV) −66.6 ± 3.33 −67.1 ± 1.22  0.733 
Input resistance (MΩ)  210.3 ± 30.7  191.0 ± 11.6  0.240 
AP threshold (mV) −35.7 ± 2.21 −33.7 ± 1.34  0.356 
AP half-width (ms)  0.56 ± 0.02  0.55 ± 0.03  0.868 
Afterhyperpolarization (mV)  16.2 ± 3.46  14.4 ± 1.76  0.655 
AMPA EPSC amplitude (pA)  72.4 ± 14.2  78.6 ± 7.2   0.616 
AMPA EPSC decay (ms)  4.25 ± 0.53  3.92 ± 0.42  0.925 
AMPA EPSC charge (pC)  0.65 ± 0.15  0.87 ± 0.10  0.421 
AMPA EPSC 20–80% rise time (ms)  0.65 ± 0.06  0.67 ± 0.05  0.966 
NMDA EPSC amplitude (pA)   53.4 ± 12.05  8.87 ± 1.58 <0.0001
NMDA/AMPA ratio  1.02 ± 0.12  0.19 ± 0.02 <0.0001

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Impermeable Interneurons resting membrane potential (mV) -66.6 ± 3.33 (19) -66.6 (mV) Data Table
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Permeable Interneurons resting membrane potential (mV) -67.1 ± 1.22 (68) -67.1 (mV) Data Table
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Impermeable Interneurons input resistance (MΩ) 210.3 ± 30.7 (19) 210.3 (MΩ) Data Table
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Permeable Interneurons input resistance (MΩ) 191.0 ± 11.6 (68) 191.0 (MΩ) Data Table
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Impermeable Interneurons spike threshold (mV) -35.7 ± 2.21 (19) -35.7 (mV) Data Table
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Permeable Interneurons spike threshold (mV) -33.7 ± 1.34 (68) -33.7 (mV) Data Table
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Impermeable Interneurons spike half-width (ms) 0.56 ± 0.02 (19) 0.56 (ms) Data Table
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Permeable Interneurons spike half-width (ms) 0.55 ± 0.03 (68) 0.55 (ms) Data Table
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Impermeable Interneurons AHP amplitude (mV) 16.2 ± 3.46 (19) 16.2 (mV) Data Table
Neocortex basket cell Prefrontal Cortex Fast Spiking Calcium Permeable Interneurons AHP amplitude (mV) 14.4 ± 1.76 (68) 14.4 (mV) Data Table