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Article: Impaired inhibitory control of cortical synchronization in fragile X syndrome.

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Paluszkiewicz SM; Olmos-Serrano JL; Corbin JG; Huntsman MM
J. Neurophysiol., 2011


Table 1.

Passive and active membrane properties

WT Fmr1 KO P Value
n 16 9
Rm, MΩ 398 ± 23 496 ± 54 0.067
Vm, mV −54.5 ± 0.8 −54.4 ± 1.4 0.91
Membrane constant, ms 36.4 ± 3.7 38.6 ± 4.1 0.71
Cm, pF 92.1 ± 8.4 80.8 ± 8.6 0.40
AP half-width, ms 1.98 ± 0.13 2.25 ± 0.17 0.21
AP amplitude, mV 64.0 ± 2.5 59.3 ± 2.4 0.23
AP time to peak, ms 1.37 ± 0.02 1.28 ± 0.02 0.013*
Threshold current, pA 16.9 ± 2.4 18.9 ± 2.6 0.60

  • Values are means ± SE for passive and active properties of layer II/III low-threshold-spiking interneurons from wild-type (WT) and Fmr1 knockout (KO) mice; n = no. of neurons. Rm, membrane resistance; Vm, resting membrane potential; Cm, membrane capacitance; AP, action potential.

  • ↵* P < 0.05.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex Martinotti cell neocortex layer 2/3 low-threshold spiking inhibitory interneuron resting membrane potential (mV) -54.5 ± 0.8 (16) -54.5 (mV) Data Table
Neocortex Martinotti cell neocortex layer 2/3 low-threshold spiking inhibitory interneuron membrane time constant (ms) 36.4 ± 3.7 (16) 36.4 (ms) Data Table
Neocortex Martinotti cell neocortex layer 2/3 low-threshold spiking inhibitory interneuron cell capacitance (pF) 92.1 ± 8.4 (16) 92.1 (pF) Data Table
Neocortex Martinotti cell neocortex layer 2/3 low-threshold spiking inhibitory interneuron spike half-width (ms) 1.98 ± 0.13 (16) 1.98 (ms) Data Table
Neocortex Martinotti cell neocortex layer 2/3 low-threshold spiking inhibitory interneuron spike amplitude (mV) 64.0 ± 2.5 (16) 64.0 (mV) Data Table
Neocortex Martinotti cell neocortex layer 2/3 low-threshold spiking inhibitory interneuron spike rise time (ms) 1.37 ± 0.02 (16) 1.37 (ms) Data Table
Neocortex Martinotti cell neocortex layer 2/3 low-threshold spiking inhibitory interneuron rheobase (pA) 16.9 ± 2.4 (16) 16.9 (pA) Data Table
Neocortex Martinotti cell neocortex layer 2/3 low-threshold spiking inhibitory interneuron input resistance (MΩ) 398.0 ± 23.0 (16) 398.0 (MΩ) Data Table