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Article: Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.

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Weston MC; Chen H; Swann JW
Front Mol Neurosci, 2014


Passive membrane and AP properties of Pten- and Tsc1-ko neurons.

Pten
 Tsc1
Control, n = 32 Pten-ko, n = 34 Control, n = 33 Tsc1-ko, n = 36
V(rest) (mV) -58.0 ± 2.2 -62.1 ± 1.9 -59.7 ± 2.1 -63.1 ± 2.4
R(input) (MΩ) 438 ± 31 359 ± 26* 390 ± 36 302 ± 26*
Time constant (ms) 34.2 ± 3.3 34.1 ± 2.9 32.3 ± 2.5 34.8 ± 2.6
Cm (pF) 81.3 ± 5.7 99.6 ± 7.0* 79.5 ± 5.7 108.0 ± 8.5**
AP threshold (mV) -29.1 ± 1.0 -31.9 ± 1.3 -32.9 ± 1.2 -35.6 ± 1.3
AP amplitude (mV) 88.4 ± 5.2 74.3 ± 3.0* 66.7 ± 2.8 57.6 ± 1.9*
AP half-width (ms) 1.16 ± 0.08 1.61 ± 0.14** 1.26 ± 0.09 1.58 ± 0.12*
Current to first AP (pA) 176 ± 17 189 ± 12 155 ± 13 177 ± 9
Measurements are shown as mean ± SEM; *p ≤ 0.05, **p ≤ 0.01 compared to control with unpaired t-test or Mann–Whitney.
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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Glutamatergic hippocampal autaptic neuron membrane time constant (ms) 34.2 ± 3.3 (32) 34.2 (ms) Data Table
Other Glutamatergic hippocampal autaptic neuron membrane time constant (ms) 32.3 ± 2.5 32.3 (ms) Data Table
Other Glutamatergic hippocampal autaptic neuron cell capacitance (pF) 81.3 ± 5.7 (32) 81.3 (pF) Data Table
Other Glutamatergic hippocampal autaptic neuron cell capacitance (pF) 79.5 ± 5.7 79.5 (pF) Data Table
Other Glutamatergic hippocampal autaptic neuron resting membrane potential -58.0 ± 2.2 (32) -58.0 (mV) Data Table
Other Glutamatergic hippocampal autaptic neuron spike threshold (mV) -29.1 ± 1.0 (32) -29.1 (mV) Data Table
Other Glutamatergic hippocampal autaptic neuron spike threshold (mV) -32.9 ± 1.2 -32.9 (mV) Data Table
Other Glutamatergic hippocampal autaptic neuron spike amplitude (mV) 88.4 ± 5.2 (32) 88.4 (mV) Data Table
Other Glutamatergic hippocampal autaptic neuron spike amplitude (mV) 66.7 ± 2.8 66.7 (mV) Data Table
Other Glutamatergic hippocampal autaptic neuron spike half-width (ms) 1.16 ± 0.08 (32) 1.16 (ms) Data Table
Other Glutamatergic hippocampal autaptic neuron spike half-width (ms) 1.26 ± 0.09 1.26 (ms) Data Table
Other Glutamatergic hippocampal autaptic neuron rheobase (pA) 176.0 ± 17.0 (32) 176.0 (pA) Data Table
Other Glutamatergic hippocampal autaptic neuron rheobase (pA) 155.0 ± 13.0 155.0 (pA) Data Table
Other Glutamatergic hippocampal autaptic neuron resting membrane potential -59.7 ± 2.1 -59.7 (mV) Data Table
Other Glutamatergic hippocampal autaptic neuron input resistance 438.0 ± 31.0 (32) 438.0 (MΩ) Data Table
Other Glutamatergic hippocampal autaptic neuron input resistance 390.0 ± 36.0 390.0 (MΩ) Data Table