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Article: A functional null mutation of SCN1B in a patient with Dravet syndrome.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL
J. Neurosci., 2009

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell input resistance (MΩ) 156.99 ± 5.97 (34) 156.99 (MΩ) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 142.6 ± 27.68 (34) 142.6 (MΩ) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -72.96 ± 0.54 (34) -72.96 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -71.99 ± 1.21 (34) -71.99 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 72.59 ± 1.6 (34) 72.59 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 69.29 ± 2.9 (34) 69.29 (mV) Data Table
Hippocampus CA1 pyramidal cell spike peak (mV) 35.48 ± 1.91 (34) 35.48 (mV) Data Table
Hippocampus CA1 pyramidal cell spike peak (mV) 38.77 ± 1.49 (34) 38.77 (mV) Data Table
Hippocampus CA1 pyramidal cell spike rise time (ms) 0.61 ± 0.02 (34) 0.61 (ms) Data Table
Hippocampus CA1 pyramidal cell spike rise time (ms) 0.76 ± 0.03 (34) 0.76 (ms) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -33.81 ± 2.0 (34) -33.81 (mV) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -33.82 ± 0.75 (34) -33.82 (mV) Data Table

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Metadata values

Experimental condition Value
RecTemp 30.0
AnimalAge 17.0 - 19.0
Strain C57BL
PrepType in vitro
ElectrodeType Patch-clamp
Species Mice
ExternalSolution 5.0
external_1_Mg 2.5
external_1_Ca 1.3
external_1_Na 146.0
external_1_Cl 129.1
external_1_K 2.5
InternalSolution 5.0
internal_1_pH 7.3
internal_1_Mg 2.0
internal_1_Ca 1.0
internal_1_Na 5.0
internal_1_Cl 7.0
JxnPotential Unreported
internal_0_pH 7.26
internal_0_Mg 2.0
internal_0_Na 17.0
internal_0_K 135.0
internal_0_GTP 3.0
internal_0_ATP 4.0
internal_0_HEPES 10.0
internal_0_Cl 24.0
external_0_Mg 2.5
external_0_Na 146.0
external_0_K 2.5
external_0_Cl 129.1
external_0_Ca 1.3
external_0_glucose 11.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
1929 A functional null mutation of SCN1B in a patient with Dravet syndrome. Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL J. Neurosci. 2009 False 6 Shreejoy Tripathy, Ryan Sefidpour, Dawson Born, 2
1925 A functional null mutation of SCN1B in a patient with Dravet syndrome. Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL J. Neurosci. 2009 False 2 0
1926 A functional null mutation of SCN1B in a patient with Dravet syndrome. Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL J. Neurosci. 2009 False 2 0
1927 A functional null mutation of SCN1B in a patient with Dravet syndrome. Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL J. Neurosci. 2009 False 2 0
1928 A functional null mutation of SCN1B in a patient with Dravet syndrome. Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL J. Neurosci. 2009 False 0 None
1930 A functional null mutation of SCN1B in a patient with Dravet syndrome. Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL J. Neurosci. 2009 False 0 None