Article: Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Weston MC; Chen H; Swann JW Front Mol Neurosci, 2014
Passive membrane and AP properties of Pten- and Tsc1-ko neurons.
Pten |
Tsc1 |
|||
---|---|---|---|---|
Control, |
Pten-ko, |
Control, |
Tsc1-ko, |
|
-58.0 ± 2.2 | -62.1 ± 1.9 | -59.7 ± 2.1 | -63.1 ± 2.4 | |
438 ± 31 | 359 ± 26* | 390 ± 36 | 302 ± 26* | |
Time constant (ms) | 34.2 ± 3.3 | 34.1 ± 2.9 | 32.3 ± 2.5 | 34.8 ± 2.6 |
Cm (pF) | 81.3 ± 5.7 | 99.6 ± 7.0* | 79.5 ± 5.7 | 108.0 ± 8.5** |
AP threshold (mV) | -29.1 ± 1.0 | -31.9 ± 1.3 | -32.9 ± 1.2 | -35.6 ± 1.3 |
AP amplitude (mV) | 88.4 ± 5.2 | 74.3 ± 3.0* | 66.7 ± 2.8 | 57.6 ± 1.9* |
AP half-width (ms) | 1.16 ± 0.08 | 1.61 ± 0.14** | 1.26 ± 0.09 | 1.58 ± 0.12* |
Current to first AP (pA) | 176 ± 17 | 189 ± 12 | 155 ± 13 | 177 ± 9 |