Table 1.
Summary of control model cell and synaptic parameters
| Intrinsic Bursting | Regular Firing | Inhibitory | |
|---|---|---|---|
| Number of cells | 100 | 300 | 100 |
| Input resistance, MΩ | 45 | 110 | 164 |
| Membrane time constant, ms | 20 | 20 | 15 |
| Resting potential, mV | −60 | −60 | −60 |
| Synaptic delay, ms | 1.2 ± 0.6 | 1.2 ± 0.6 | 1.2 ± 0.6 |
| Extrinsic input synaptic conductance, nS | 8 | 4 | 1.5 |
| Mean recurrent input synaptic conductance, nS | |||
| AMPA | 2 | 1 | 1 |
| NMDA | 1 | 0.5 | |
| GABAA | 20 | 4 | |
| GABAB | 0.5 | 0.2 |
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Synaptic conductances are the peak amplitude of each time-dependent conductance. For simulations of epileptogenesis, input resistances and time constants of excitatory neurons were increased and recurrent input conductances were varied as indicated in text; the recurrent conductance values listed here are the “standard” values, corresponding to “1.0” in Fig. 5.