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Article: Early excitability changes in lumbar motoneurons of transgenic SOD1G85R and SOD1G(93A-Low) mice.

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Pambo-Pambo A; Durand J; Gueritaud JP
J. Neurophysiol., 2009


Table 2.

Action potential parameters

WT G85R G93A-Low
Spike parameters
    n 33 25 13
    AP thr, mV −35.1 ± 1.4 −32.5 ± 1.3 −35.8 ± 1.8
    Peak amp, mV 58.7 ± 1.4 61.6 ± 1.5 51.94 ± 2.79*
    Time to peak, ms 0.9 ± 0.1 0.9 ± 0.1 0.89 ± 0.07
    Half-width, ms 0.8 ± 0.3 0.9 ± 0.1 1.46 ± 0.13***
    Max rise slope, mV/ms 151.6 ± 7.4 163.1 ± 7.3 101.84 ± 8.00***
    Max decay slope, mV/ms −82.1 ± 4.6 −77.0 ± 4.2 −60.20 ± 5.87*
AHP parameters
    n 33 22 13
    AHP peak amp, mV −11.6 ± 0.5 −12.2 ± 0.7 −11.4 ± 0.6
    AHP width, ms 91.4 ± 6.5 100.2 ± 6.5 111.8 ± 11.4
    Time to peak, ms 15.1 ± 0.8 14.5 ± 1.0 16.2 ± 1.4
    Half-width, ms 45.4 ± 2.9 47.5 ± 2.3 53.3 ± 4.2
  • All values are means±SE. AP thr, threshold of action potential; peak amp, potential difference between maximum of spike potential and spike threshold; time to peak, time needed for potential to rise from spike threshold to maximum value; half-width, time spent by membrane potential >50% of the maximum amplitude of action potential; spike max rise slope, maximum slope on the depolarizing phase of spike potential; spike max decay slope, maximum slope on the repolarizing phase of spike potential; AHP peak amp, maximum value of post-spike after-hyperpolarization measured from spike threshold; AHP width, duration of post-spike after-hyperpolarization measured from end of spike potential to return of membrane potential to threshold value.

  • * P < 0.05,

  • *** P < 0.005, nonparametric permutation exact test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Spinal cord ventral horn motor neuron alpha spinal cord lumbar motor neuron spike threshold (mV) -35.1 ± 1.4 (33) -35.1 (mV) Data Table
Spinal cord ventral horn motor neuron alpha spinal cord lumbar motor neuron spike amplitude (mV) 58.7 ± 1.4 (33) 58.7 (mV) Data Table
Spinal cord ventral horn motor neuron alpha spinal cord lumbar motor neuron spike rise time (ms) 0.9 ± 0.1 (33) 0.9 (ms) Data Table
Spinal cord ventral horn motor neuron alpha spinal cord lumbar motor neuron spike half-width (ms) 0.8 ± 0.3 (33) 0.8 (ms) Data Table
Spinal cord ventral horn motor neuron alpha spinal cord lumbar motor neuron spike max rise slope (mV/ms) 151.6 ± 7.4 (33) 151.6 (mV/ms) Data Table
Spinal cord ventral horn motor neuron alpha spinal cord lumbar motor neuron spike max decay slope (mV/ms) -82.1 ± 4.6 (33) 82.1 (mV/ms) Data Table
Spinal cord ventral horn motor neuron alpha spinal cord lumbar motor neuron AHP amplitude (mV) -11.6 ± 0.5 (33) 11.6 (mV) Data Table
Spinal cord ventral horn motor neuron alpha spinal cord lumbar motor neuron AHP duration (ms) 45.4 ± 2.9 (33) 45.4 (ms) Data Table