Values are mean ± S.E. (n).
|
Article: NMDA receptor function in mouse models of Huntington disease.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Cepeda C; Ariano MA; Calvert CR; Flores-Hernández J; Chandler SH; Leavitt BR; Hayden MR; Levine MS J. Neurosci. Res., 2001
| WT | R6/2-Presymptomatic | WT | R6/2-Symptomatic | |
|---|---|---|---|---|
| ||||
| Basic membrane properties | ||||
| Capacitance (pF) | 81 ± 13 (13) | 89 ± 5 (29) | 83 ± 5 (16) | 68 ± 4 (16) P < 0.025 |
| Input resistance (MΩ) | 89 ± 16 (13) | 126 ± 21 (29) | 106 ± 28 (16) | 209 ± 31 (16) P < 0.025 |
| Time constant (msec) | 1.7 ± 0.3 (13) | 1.7 ± 0.1 (29) | 1.7 ± 0.1 (16) | 1.4 ± 0.1 (16) P < 0.05 |
| Voltage-gated Ca2+ peak currents | ||||
| Step Ca2+ current (pA) | 703 ± 76 (11) | 795 ± 74 (28) | 951 ± 124 (11) | 540 ± 81 (13) P < 0.01 |
| Current density (pA/pF) | 8.9 ± 0.9 (11) | 9.3 ± 0.9 (28) | 12.2 ± 1.7 (11) | 8.0 ± 1.7 (13) P < 0.05 |
| Ramp Ca2+ current (pA) | 636 ± 104 (13) | 799 ± 102 (29) | 900 ± 133 (14) | 389 ± 71 (15) P < 0.025 |
| Current density (pA/pF) | 8.2 ± 1.5 (13) | 9.0 ± 1.1 (29) | 11.4 ± 1.8 (14) | 5.9 ± 1.1 (15) P < 0.01 |
| Peak Ca2+ concentration in response to voltage ramps | ||||
| Basal Ca2+ (nM) | 72.3 ± 7.2 (9) | 72.8 ± 5 (21) | 59.3 ± 5.5 (15) | 55.1 ± 3.8 (15) |
| Basal Ca2+ (ΔF/F) | 0.20 ± 0.017 (9) | 0.20 ± 0.012 (21) | 0.17 ± 0.013 (15) | 0.16 ± 0.009 (15) |
| % Change (nM) | 279 ± 44 (9) | 285 ± 34 (21) | 215 ± 38 (15) | 143 ± 20 (15) P < 0.05 |
| % Change (ΔF/F) | 185 ± 24 (9) | 188 ± 20 (21) | 151 ± 21 (15) | 109 ± 14 (15) P < 0.05 |
| Time to peak (sec) | 5.1 ± 0.3 (9) | 4.5 ± 0.1 (21) P < 0.05 | 5.2 ± 0.2 (15) | 5.8 ± 0.3 (15) P < 0.05 |