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Article: Insulin facilitates repetitive spike firing in rat insular cortex via phosphoinositide 3-kinase but not mitogen activated protein kinase cascade.

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Takei H; Fujita S; Shirakawa T; Koshikawa N; Kobayashi M
Neuroscience, 2010


Table 1Effects of 100 nM insulin on intrinsic electrophysiological properties of layer II/III pyramidal cells
ControlInsulin
Mean±SEMnMean±SEMn
Vm† (mV)−73.5±2.220−74.2±1.920
Input resistance (MΩ)28.3±1.72028.7±1.620
Action potential
1st spike amplitude (mV)72.6±1.81869.6±2.318
1st spike half duration (ms)1.0±0.0181.0±0.018
10th spike amplitude (mV)63.8±2.01862.2±2.018
10th spike half duration (ms)1.5±0.1181.6±0.118
Rheobase (nA)0.55±0.06190.53±0.0619
Action potential threshold
1st threshold (mV)−51.3±1.219−53.6±1.2⁎19
2nd threshold (mV)−47.4±1.319−49.4±1.4⁎19
Last threshold (mV)−44.3±1.916−46.6±1.7⁎16
mAHP†† amplitude
1st mAHP amplitude (mV)3.8±0.7192.4±1.019
2nd mAHP amplitude (mV)8.0±0.7196.8±0.719
Last mAHP amplitude (mV)14.2±1.01912.9±1.119
Spike interval
1st inter-spike interval (ms)17.0±4.31914.8±3.319
2nd inter-spike interval (ms)33.8±7.21929.1±6.2⁎19
Last inter-spike interval (ms)99.6±13.21867.7±6.7⁎18
Frequency at 1 nA (Hz)13.8±1.81818.1±2.7⁎18
f/I slope (Hz/nA)23.7±2.31929.5±3.2⁎19
sAHP††† amplitude (mV)3.5±0.6194.0±0.719
†Resting membrane potential;††Medium-duration afterhyperpolarization;†††Slow afterhyperpolarization.⁎P<0.05(paired t-test).

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 resting membrane potential (mV) -73.5 ± 2.2 (19) -73.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 firing frequency (Hz) 13.8 ± 1.8 (19) 13.8 (Hz) Data Table
Neocortex pyramidal cell layer 2-3 FI slope (Hz/nA) 23.7 ± 2.3 (19) 23.7 (Hz/nA) Data Table
Neocortex pyramidal cell layer 2-3 slow AHP amplitude from resting (mV) 3.5 ± 0.6 (19) 3.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 input resistance (MΩ) 28.3 ± 1.7 (19) 28.3 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 spike amplitude (mV) 72.6 ± 1.8 (19) 72.6 (mV) Data Table
Neocortex pyramidal cell layer 2-3 spike half-width (ms) 1.0 (19) 1.0 (ms) Data Table
Neocortex pyramidal cell layer 2-3 other (ms) 1.5 ± 0.1 (19) -- Data Table
Neocortex pyramidal cell layer 2-3 rheobase (nA) 0.55 ± 0.06 (19) 550.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 spike threshold (mV) -51.3 ± 1.2 (19) -51.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 medium AHP amplitude (mV) 3.8 ± 0.7 (19) 3.8 (mV) Data Table