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Neocortex pyramidal cell layer 2-3 (Definition)

Electrophysiological properties of Neocortex pyramidal cell layer 2-3s from literature:

  • Reports: Blue dots indicate human-curated values; Orange dots indicate non-human curated values
  • Mean+SD: mean and standard deviation of human-curated neuron measurements
  • All neurons: mean and standard deviation computed over all neurons in database
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  • Legend: Blue dots = text-mined values human curated; Orange dots = text-mined values not human curated

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Articles with extracted electrophysiology properties:

Article Title Authors Journal Year Electrophys values Neuron types
Specificity in the interaction of HVA Ca2+ channel types with Ca2+-dependent AHPs and firing behavior in neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Pineda JC; Waters RS; Foehring RC J. Neurophysiol. 1998 12 1
A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Shruti S; Clem RL; Barth AL Neurobiol. Dis. 2008 8 1
Relationships between intracellular calcium and afterhyperpolarizations in neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Abel HJ; Lee JC; Callaway JC; Foehring RC J. Neurophysiol. 2004 4 1
Prolonged synaptic integration in perirhinal cortical neurons. (NeuroElectro data) (PubMed) Beggs JM; Moyer JR; McGann JP; Brown TH J. Neurophysiol. 2000 10 1
Threshold firing frequency-current relationships of neurons in rat somatosensory cortex: type 1 and type 2 dynamics. (NeuroElectro data) (PubMed) Tateno T; Harsch A; Robinson HP J. Neurophysiol. 2004 16 2
Dopamine increases inhibition in the monkey dorsolateral prefrontal cortex through cell type-specific modulation of interneurons. (NeuroElectro data) (PubMed) Kröner S; Krimer LS; Lewis DA; Barrionuevo G Cereb. Cortex 2007 36 2
Insulin facilitates repetitive spike firing in rat insular cortex via phosphoinositide 3-kinase but not mitogen activated protein kinase cascade. (NeuroElectro data) (PubMed) Takei H; Fujita S; Shirakawa T; Koshikawa N; Kobayashi M Neuroscience 2010 15 1
Neuromodulation by a cytokine: interferon-beta differentially augments neocortical neuronal activity and excitability. (NeuroElectro data) (PubMed) Hadjilambreva G; Mix E; Rolfs A; Müller J; Strauss U J. Neurophysiol. 2005 18 2
Subtype-specific dendritic Ca(2+) dynamics of inhibitory interneurons in the rat visual cortex. (NeuroElectro data) (PubMed) Cho KH; Jang JH; Jang HJ; Kim MJ; Yoon SH; Fukuda T; Tennigkeit F; Singer W; Rhie DJ J. Neurophysiol. 2010 39 3
Interlaminar differences of intrinsic properties of pyramidal neurons in the auditory cortex of mice. (NeuroElectro data) (PubMed) Huggenberger S; Vater M; Deisz RA Cereb. Cortex 2009 48 2
Functional roles of Kv1 channels in neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Guan D; Lee JC; Higgs MH; Spain WJ; Foehring RC J. Neurophysiol. 2007 10 1
The roles of somatostatin-expressing (GIN) and fast-spiking inhibitory interneurons in UP-DOWN states of mouse neocortex. (NeuroElectro data) (PubMed) Fanselow EE; Connors BW J. Neurophysiol. 2010 6 3
Glutamatergic nonpyramidal neurons from neocortical layer VI and their comparison with pyramidal and spiny stellate neurons. (NeuroElectro data) (PubMed) Andjelic S; Gallopin T; Cauli B; Hill EL; Roux L; Badr S; Hu E; Tamás G; Lambolez B J. Neurophysiol. 2009 30 4
Maturation of intrinsic and synaptic properties of layer 2/3 pyramidal neurons in mouse auditory cortex. (NeuroElectro data) (PubMed) Oswald AM; Reyes AD J. Neurophysiol. 2008 24 1
Lack of depolarization-induced suppression of inhibition (DSI) in layer 2/3 interneurons that receive cannabinoid-sensitive inhibitory inputs. (NeuroElectro data) (PubMed) Lemtiri-Chlieh F; Levine ES J. Neurophysiol. 2007 27 3
Cluster analysis-based physiological classification and morphological properties of inhibitory neurons in layers 2-3 of monkey dorsolateral prefrontal cortex. (NeuroElectro data) (PubMed) Krimer LS; Zaitsev AV; Czanner G; Kröner S; González-Burgos G; Povysheva NV; Iyengar S; Barrionuevo G; Lewis DA J. Neurophysiol. 2005 77 4
Effects of temperature on calcium transients and Ca2+-dependent afterhyperpolarizations in neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Lee JC; Callaway JC; Foehring RC J. Neurophysiol. 2005 16 1
Electrophysiological classes of cat primary visual cortical neurons in vivo as revealed by quantitative analyses. (NeuroElectro data) (PubMed) Nowak LG; Azouz R; Sanchez-Vives MV; Gray CM; McCormick DA J. Neurophysiol. 2003 8 3
Characterization of neuronal migration disorders in neocortical structures. II. Intracellular in vitro recordings. (NeuroElectro data) (PubMed) Luhmann HJ; Karpuk N; Qü M; Zilles K J. Neurophysiol. 1998 6 1
Epileptogenesis following neocortical trauma from two sources of disinhibition. (NeuroElectro data) (PubMed) Yang L; Benardo LS J. Neurophysiol. 1997 12 2
Specialized cortical subnetworks differentially connect frontal cortex to parahippocampal areas. (NeuroElectro data) (PubMed) Hirai Y; Morishima M; Karube F; Kawaguchi Y J. Neurosci. 2012 24 3
Local connections of excitatory neurons to corticothalamic neurons in the rat barrel cortex. (NeuroElectro data) (PubMed) Tanaka YR; Tanaka YH; Konno M; Fujiyama F; Sonomura T; Okamoto-Furuta K; Kameda H; Hioki H; Furuta T; Nakamura KC; Kaneko T J. Neurosci. 2011 48 3
Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease. (NeuroElectro data) (PubMed) Cummings DM; André VM; Uzgil BO; Gee SM; Fisher YE; Cepeda C; Levine MS J. Neurosci. 2009 14 1
M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons. (NeuroElectro data) (PubMed) Gulledge AT; Bucci DJ; Zhang SS; Matsui M; Yeh HH J. Neurosci. 2009 6 2
Sensory experience alters cortical connectivity and synaptic function site specifically. (NeuroElectro data) (PubMed) Cheetham CE; Hammond MS; Edwards CE; Finnerty GT J. Neurosci. 2007 4 1
Background synaptic activity is sparse in neocortex. (NeuroElectro data) (PubMed) Waters J; Helmchen F J. Neurosci. 2006 12 2
A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex. (NeuroElectro data) (PubMed) Aramakis VB; Hsieh CY; Leslie FM; Metherate R J. Neurosci. 2000 24 1
Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex. (NeuroElectro data) (PubMed) Avermann M; Tomm C; Mateo C; Gerstner W; Petersen CC J. Neurophysiol. 2012 21 1
Synaptic organization and input-specific short-term plasticity in anterior cingulate cortical neurons with intact thalamic inputs. (NeuroElectro data) (PubMed) Lee CM; Chang WC; Chang KB; Shyu BC Eur. J. Neurosci. 2007 35 3
Widely integrative properties of layer 5 pyramidal cells support a role for processing of extralaminar synaptic inputs in rat neocortex. (NeuroElectro data) (PubMed) Telfeian AE; Connors BW Neurosci. Lett. 2003 16 2
The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. (NeuroElectro data) (PubMed) Lefort S; Tomm C; Floyd Sarria JC; Petersen CC Neuron 2009 36 3
Postnatal alterations of the inhibitory synaptic responses recorded from cortical pyramidal neurons in the Lis1/sLis1 mutant mouse. (NeuroElectro data) (PubMed) Valdés-Sánchez L; Escámez T; Echevarria D; Ballesta JJ; Tabarés-Seisdedos R; Reiner O; Martinez S; Geijo-Barrientos E Mol. Cell. Neurosci. 2007 10 1
Activation of alpha1-adrenoceptors increases firing frequency through protein kinase C in pyramidal neurons of rat visual cortex. (NeuroElectro data) (PubMed) Kobayashi M; Sasabe T; Shiohama Y; Koshikawa N Neurosci. Lett. 2008 18 1
Hippocampal heterotopia with molecular and electrophysiological properties of neocortical neurons. (NeuroElectro data) (PubMed) Castro PA; Pleasure SJ; Baraban SC Neuroscience 2002 20 2
Postnatal maturation of somatostatin-expressing inhibitory cells in the somatosensory cortex of GIN mice. (NeuroElectro data) (PubMed) Kinnischtzke AK; Sewall AM; Berkepile JM; Fanselow EE Front Neural Circuits 2012 52 2
Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. (NeuroElectro data) (PubMed) Luebke JI; Medalla M; Amatrudo JM; Weaver CM; Crimins JL; Hunt B; Hof PR; Peters A Cereb. Cortex 2015 32 1
Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex. (NeuroElectro data) (PubMed) Gonzalez-Burgos G; Miyamae T; Pafundo DE; Yoshino H; Rotaru DC; Hoftman G; Datta D; Zhang Y; Hammond M; Sampson AR; Fish KN; Bard Ermentrout G; Lewis DA Cereb. Cortex 2015 18 1
Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia. (NeuroElectro data) (PubMed) Brill J; Huguenard JR Cereb. Cortex 2010 14 2
Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortex. (NeuroElectro data) (PubMed) González-Burgos G; Krimer LS; Urban NN; Barrionuevo G; Lewis DA Cereb. Cortex 2004 15 2
Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat. (NeuroElectro data) (PubMed) Lambe EK; Goldman-Rakic PS; Aghajanian GK Cereb. Cortex 2000 12 2
Properties of excitatory synaptic responses in fast-spiking interneurons and pyramidal cells from monkey and rat prefrontal cortex. (NeuroElectro data) (PubMed) Povysheva NV; Gonzalez-Burgos G; Zaitsev AV; Kröner S; Barrionuevo G; Lewis DA; Krimer LS Cereb. Cortex 2006 24 2
Morphological and physiological characterization of pyramidal neuron subtypes in rat medial prefrontal cortex. (NeuroElectro data) (PubMed) van Aerde KI; Feldmeyer D Cereb. Cortex 2015 122 2
Transient Hearing Loss Within a Critical Period Causes Persistent Changes to Cellular Properties in Adult Auditory Cortex. (NeuroElectro data) (PubMed) Mowery TM; Kotak VC; Sanes DH Cereb. Cortex 2015 35 2
Myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice. (NeuroElectro data) (PubMed) Sutor B; Schmolke C; Teubner B; Schirmer C; Willecke K Cereb. Cortex 2000 6 1
Delayed effects of corticosterone on slow after-hyperpolarization potentials in mouse hippocampal versus prefrontal cortical pyramidal neurons. (NeuroElectro data) (PubMed) Pillai AG; Henckens MJ; Fernández G; Joëls M PLoS ONE 2014 40 2
Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat. (NeuroElectro data) (PubMed) Wayman WN; Chen L; Napier TC; Hu XT Eur. J. Neurosci. 2015 5 1
Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex. (NeuroElectro data) (PubMed) Dong H; Shao Z; Nerbonne JM; Burkhalter A J. Comp. Neurol. 2004 4 1
Distinct balance of excitation and inhibition in an interareal feedforward and feedback circuit of mouse visual cortex. (NeuroElectro data) (PubMed) Yang W; Carrasquillo Y; Hooks BM; Nerbonne JM; Burkhalter A J. Neurosci. 2013 28 2
Arc regulates experience-dependent persistent firing patterns in frontal cortex. (NeuroElectro data) (PubMed) Ren M; Cao V; Ye Y; Manji HK; Wang KH J. Neurosci. 2014 8 1
Thalamic control of layer 1 circuits in prefrontal cortex. (NeuroElectro data) (PubMed) Cruikshank SJ; Ahmed OJ; Stevens TR; Patrick SL; Gonzalez AN; Elmaleh M; Connors BW J. Neurosci. 2012 46 2
Spatial profile of excitatory and inhibitory synaptic connectivity in mouse primary auditory cortex. (NeuroElectro data) (PubMed) Levy RB; Reyes AD J. Neurosci. 2012 50 4
Contributions of diverse excitatory and inhibitory neurons to recurrent network activity in cerebral cortex. (NeuroElectro data) (PubMed) Neske GT; Patrick SL; Connors BW J. Neurosci. 2015 70 6
Neural precursor lineages specify distinct neocortical pyramidal neuron types. (NeuroElectro data) (PubMed) Tyler WA; Medalla M; Guillamon-Vivancos T; Luebke JI; Haydar TF J. Neurosci. 2015 28 1
Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. (NeuroElectro data) (PubMed) Amatrudo JM; Weaver CM; Crimins JL; Hof PR; Rosene DL; Luebke JI J. Neurosci. 2012 18 1
Decorrelating action of inhibition in neocortical networks. (NeuroElectro data) (PubMed) Sippy T; Yuste R J. Neurosci. 2013 18 3
Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function. (NeuroElectro data) (PubMed) Rebello TJ; Yu Q; Goodfellow NM; Caffrey Cagliostro MK; Teissier A; Morelli E; Demireva EY; Chemiakine A; Rosoklija GB; Dwork AJ; Lambe EK; Gingrich JA; Ansorge MS J. Neurosci. 2014 10 1
COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex. (NeuroElectro data) (PubMed) Lacroix A; Toussay X; Anenberg E; Lecrux C; Ferreirós N; Karagiannis A; Plaisier F; Chausson P; Jarlier F; Burgess SA; Hillman EM; Tegeder I; Murphy TH; Hamel E; Cauli B J. Neurosci. 2015 24 2
Specific Early and Late Oddball-Evoked Responses in Excitatory and Inhibitory Neurons of Mouse Auditory Cortex. (NeuroElectro data) (PubMed) Chen IW; Helmchen F; Lütcke H J. Neurosci. 2015 18 2
Delayed and Temporally Imprecise Neurotransmission in Reorganizing Cortical Microcircuits. (NeuroElectro data) (PubMed) Barnes SJ; Cheetham CE; Liu Y; Bennett SH; Albieri G; Jorstad AA; Knott GW; Finnerty GT J. Neurosci. 2015 8 1
Effects of ethanol on rat somatosensory cortical neurons. (NeuroElectro data) (PubMed) Sessler FM; Hsu FC; Felder TN; Zhai J; Lin RC; Wieland SJ; Kosobud AE Brain Res. 1998 18 2
Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine. (NeuroElectro data) (PubMed) Guan D; Armstrong WE; Foehring RC J. Neurophysiol. 2015 42 2
Altered dendritic complexity affects firing properties of cortical layer 2/3 pyramidal neurons in mice lacking the 5-HT3A receptor. (NeuroElectro data) (PubMed) van der Velden L; van Hooft JA; Chameau P J. Neurophysiol. 2012 9 1
Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex. (NeuroElectro data) (PubMed) Elstrott J; Clancy KB; Jafri H; Akimenko I; Feldman DE J. Neurophysiol. 2014 14 1
Electrophysiological classes of layer 2/3 pyramidal cells in monkey prefrontal cortex. (NeuroElectro data) (PubMed) Zaitsev AV; Povysheva NV; Gonzalez-Burgos G; Lewis DA J. Neurophysiol. 2012 66 1
Strychnine-sensitive glycine receptors on pyramidal neurons in layers II/III of the mouse prefrontal cortex are tonically activated. (NeuroElectro data) (PubMed) Salling MC; Harrison NL J. Neurophysiol. 2014 14 2

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